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Neurochemical Journal

, Volume 13, Issue 3, pp 302–311 | Cite as

The Neurobiological Effects of the Combined Impact of Anti-Orthostatic Hanging and Different Ionizing Irradiations

  • K. B. Lebedeva-Georgievskaya
  • V. S. Kokhan
  • A. K. Shurtakova
  • A. A. Perevezentsev
  • V. S. Kudrin
  • A. S. Shtemberg
  • A. S. BazyanEmail author
EXPERIMENTAL ARTICLES
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Abstract—The purpose of this investigation was to study the neurobiological effects of several interplanetary flight factors: hypogravity, which was modeled in a ground-based experiment using the conventional gravitational unloading technique, a 7-day anti-orthostatic hanging (AOH), and synchronous with it long-term gamma irradiation and high-energy protons. We analyzed the animal behavior in a number of tests: the open field, elevated plus maze, passive avoidance, Morris water test, and the exchange of monoamines in key brain structures. The most interesting and paradoxical result of our study is that in some cases effects were mitigated by the combined effect of radiation and microgravity, which manifests itself both in behavior and in neurochemical changes in all five studied brain structures, despite the fact that these structures play different roles in the performance of behavior. However, the isolated treatment with both radiation and AOH caused significant changes.

Keywords:

ionizing radiation antiorthostatic display behavior concentration of monoamines and metabolites in brain structures 

Notes

FUNDING

This study was funded by programs of the Russian Academy of Sciences and grants from the Russian Foundation for Basic Research: project nos. 17-29-01002-ofi_m and 17-29-01005-ofi_m.

COMPLIANCE WITH ETHICAL STANDARDS

Ethical approval: All procedures performed in studies involving animals were in accordance with the ethical standards of bioethical commissions of the Institute of Biomedical Problems of the Russian Academy of Sciences, the Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, and the Zakusov Research Institute of Institute of Pharmacology of the Russian Academy of Sciences, Moscow, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest: The authors declare that they have no conflict of interest.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • K. B. Lebedeva-Georgievskaya
    • 1
  • V. S. Kokhan
    • 1
  • A. K. Shurtakova
    • 1
  • A. A. Perevezentsev
    • 1
  • V. S. Kudrin
    • 1
    • 3
  • A. S. Shtemberg
    • 1
  • A. S. Bazyan
    • 1
    • 2
    Email author
  1. 1.Institute of Biomedical Problems, Russian Academy of SciencesMoscowRussia
  2. 2.Zakusov Institute of Pharmacology, Russian Academy of SciencesMoscowRussia
  3. 3.Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of SciencesMoscowRussia

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