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Neurochemical Journal

, Volume 13, Issue 2, pp 113–120 | Cite as

One-Carbon Metabolism Disorders in Schizophrenia: Genetic and Therapeutic Aspects

  • T. V. ZhilyaevaEmail author
  • A. V. Sergeeva
  • A. S. Blagonravova
  • G. E. Mazo
  • A. O. Kibitov
Review Articles
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Abstract

We review the role of disorders of one-carbon metabolism (OCM) in the etiopathogenesis of schizophrenia, define directions for further research into the role of single nucleotide genetic polymorphisms of the folate pathway enzymes, and outlined future lines of studies on personalized correction of OCM disorders. The reviewed data suggest that it is necessary to perform complex studies on the genetic risk of OCM disorders, molecular mechanisms of schizophrenia pathogenesis, which involve OCM disorders, and the clinical effects of their personalized correction.

Keywords

schizophrenia one-carbon metabolism disorders folate deficiency vitamin B12 deficiency hyperhomocysteinemia genetic polymorphisms 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • T. V. Zhilyaeva
    • 1
    Email author
  • A. V. Sergeeva
    • 1
  • A. S. Blagonravova
    • 1
  • G. E. Mazo
    • 2
  • A. O. Kibitov
    • 3
  1. 1.Volga Research Medical UniversityNizhny NovgorodRussia
  2. 2.Bekhterev National Medical Research Center for Psychiatry and NeurologySt. PetersburgRussia
  3. 3.Serbskii National Medical Center for Psychiatry and NarcologyMoscowRussia

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