Neurochemical Journal

, Volume 12, Issue 1, pp 71–77 | Cite as

The Influence of Noopept on Morphological, Electrophysiological, and Biochemical Changes in the Retina during the Experimental Thrombosis of Its Vessels

  • A. V. Kolesnikov
  • A. V. Shchul’kin
  • M. V. Pisklova
  • O. I. Barenina
  • E. N. Yakusheva
  • V. S. Kudrin
  • R. U. Ostrovskaya
  • M. G. Uzbekov
  • M. M. Shishkin
Experimental Articles
  • 3 Downloads

Abstract

We studied the influence of the neuroprotective dipeptide drug noopept on the state of the retina during thrombosis of its vessels in an experiment with male chinchilla rabbits. The pathology was modeled by intravenous injection of rose Bengal at a dose of 40 mg/kg followed by transpupillary focal illumination with white light of the temporal vascular arcade for 10 min. Noopept was administered intravenously immediately after modeling thrombosis at a dose of 0.5 mg/kg, and then three times per day per os at a dose of 10 mg/kg throughout the experiment. It was found that noopept improves the functional state of the retinal neurons according to electroretinography. At the 5–7th and 14th days, noopept reduced the glutamate content in the retina by 86.8% and 84.1% compared to the control animals (p < 0.05), decreased the concentration of products of reaction with thiobarbituric acid by 17.3% and 14.9% on the 3rd and 7th days (p < 0.05), and increased the activity of glutathione-S-transferase by 34.5% on the 1st day (p < 0.05).

Keywords

noopept photoinduced retinal vascular thrombosis glutamate excitotoxicity oxidative stress ischemia modeling 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • A. V. Kolesnikov
    • 1
  • A. V. Shchul’kin
    • 1
    • 5
  • M. V. Pisklova
    • 2
  • O. I. Barenina
    • 1
  • E. N. Yakusheva
    • 1
  • V. S. Kudrin
    • 2
  • R. U. Ostrovskaya
    • 2
  • M. G. Uzbekov
    • 3
  • M. M. Shishkin
    • 4
  1. 1.Ryazan State Medical UniversityRyazanRussia
  2. 2.Zakusov Institute of PharmacologyMoscowRussia
  3. 3.Moscow Institute of PsychiatryMinistry of HealthMoscowRussia
  4. 4.Pirogov National Medical Surgery CenterMinistry of HealthMoscowRussia
  5. 5.RyazanRussia

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