Doklady Biochemistry and Biophysics

, Volume 488, Issue 1, pp 316–319 | Cite as

The Induction of the Synthesis of Interferon, CD4 and CD8 T Lymphocytes in Blood and Spleen of Mice after Oral Vaccination with the “Early” Protein HPV16 E2

  • R. K. SalyaevEmail author
  • N. I. RekoslavskayaEmail author
  • A. S. Stolbikov


High contents of interferon and CD4 and CD8 T lymphocytes were found in blood and spleen cells of mice after their oral vaccination with the “early” protein of HPV16 E2 by using ELISPOT, Western blot hybridization, and enzyme immunoassay technique. It was concluded that the “early” protein HPV16 E2 is involved in the immune system activation during control of pathogenesis and neoplasia.



Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of SciencesIrkutskRussia
  2. 2.Irkutsk Scientific Center, Siberian Branch, Russian Academy of SciencesIrkutskRussia

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