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Doklady Biochemistry and Biophysics

, Volume 485, Issue 1, pp 123–125 | Cite as

Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity

  • T. A. GudashevaEmail author
  • M. A. Konstantinopolsky
  • A. V. Tarasiuk
  • L. G. Kolik
  • S. B. Seredenin
BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY

Abstract

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5–48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • T. A. Gudasheva
    • 1
    Email author
  • M. A. Konstantinopolsky
    • 1
  • A. V. Tarasiuk
    • 1
  • L. G. Kolik
    • 1
  • S. B. Seredenin
    • 1
  1. 1.Zakusov Research Institute of Pharmacology, Russian Academy of Medical SciencesMoscowRussia

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