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Doklady Biochemistry and Biophysics

, Volume 483, Issue 1, pp 326–328 | Cite as

The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre Recombinase

  • O. A. BezborodovaEmail author
  • I. V. Alekseenko
  • E. R. Nemtsova
  • A. A. Pankratov
  • O. B. Filyukova
  • R. I. Yakubovskaya
  • M. B. Kostina
  • V. K. Potapov
  • E. D. Sverdlov
Biochemistry, Biophysics, and Molecular Biology
  • 19 Downloads

Abstract

In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre–LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • O. A. Bezborodova
    • 1
    Email author
  • I. V. Alekseenko
    • 2
    • 3
  • E. R. Nemtsova
    • 1
  • A. A. Pankratov
    • 1
  • O. B. Filyukova
    • 2
  • R. I. Yakubovskaya
    • 1
  • M. B. Kostina
    • 2
  • V. K. Potapov
    • 2
  • E. D. Sverdlov
    • 2
    • 3
  1. 1.Moscow Cancer Research Institute, Branch of the National Medical Research Center of RadiologyMinistry of Health of the Russian FederationMoscowRussia
  2. 2.Shemyakin–Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia
  3. 3.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia

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