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Doklady Biochemistry and Biophysics

, Volume 483, Issue 1, pp 293–296 | Cite as

Effect of New Derivatives of 2-Aminothiophene-3-Carboxylic Acid on Calcium-Activated Chloride Currents in Rat Neurons

  • V. V. Grigoriev
  • V. L. ZamoyskiEmail author
  • A. V. Aksinenko
  • V. B. Sokolov
  • S. O. Bachurin
Biochemistry, Biophysics, and Molecular Biology
  • 8 Downloads

Abstract

Using the patch-clamp method in the whole-cell configuration, we showed that the new derivatives of 2-aminothiophene-3-carboxylic acid, which were synthesized by us earlier, can both block (compound 1) and potentiate (compound 2) calcium-activated chloride currents in single rat cerebellar Purkinje cells.

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • V. V. Grigoriev
    • 1
  • V. L. Zamoyski
    • 1
    Email author
  • A. V. Aksinenko
    • 1
  • V. B. Sokolov
    • 1
  • S. O. Bachurin
  1. 1.Institute of Physiologically Active CompoundsRussian Academy of SciencesChernogolovka, Moscow oblastRussia

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