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Russian Journal of Organic Chemistry

, Volume 55, Issue 6, pp 874–878 | Cite as

A Convenient Synthesis of N2-Alkylated Guanines

  • H. T. Zhu
  • L. Y. Qin
  • T. Liu
  • Y. LuoEmail author
Review
  • 9 Downloads

Abstract

An improved three-step synthesis of N2-alkylated guanines has been developed starting from N2-Boc-protected 2-amino-6-chloropurine which was treated with Boc2O, and the resulting doubly N2,9-protected derivative was subjected to N2-alkylation with alkyl halides, followed by hydrolysis. The advantages of this procedure include short reaction steps, simple operations, and good yields.

Keywords

guanine N2-alkylation Boc protection 

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Notes

Acknowledgments

The authors thank the Laboratory of Organic Functional Molecules, the Sino-French Institute of ECNU, for supports.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghaiChina

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