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Russian Journal of Organic Chemistry

, Volume 55, Issue 6, pp 860–865 | Cite as

Synthesis, Characterization, and in vitro Antibacterial Evaluation of Barbituric Acid Derivatives

  • S. ShuklaEmail author
  • A. BishnoiEmail author
  • P. Devi
  • S. Kumar
  • A. Srivastava
  • K. Srivastava
  • S. Fatma
Review
  • 15 Downloads

Abstract

A series of 5,5′-(arylmethylene)bis[1,3-dimethyl-6-(methylamino)pyrimidine-2,4(1H,3H)-diones] have been synthesized by 2: 1 condensation of 1,3-dimethylbarbituric acid with armatic aldehydes in the presence of methylamine. The synthesized compounds have been characterized by 1H and 13C NMR, IR, and mass spectra and tested for their in vitro antibacterial activity against Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. Some of the compounds have shown antibacterial activity exceeding that of ampicillin used as reference drug.

Keywords

barbituric acid derivatives 5,5′-(arylmethylene)bis[1,3-dimethyl-6-(methylamino)pyrimidin-2,4(1H,3H)-diones antibacterial activity 

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Notes

Acknowledgements

The authors are thankful to the Head, Department of Chemistry, University of Lucknow, Lucknow, for providing necessary laboratory facilities; to the Director, Central Drug Research Institute (CDRI), Lucknow, India, for providing spectral data; and to the Director, Faculty of Biotechnology, Institute of Biosciences and Technology, Shri Ramswaroop Memorial Unversity, for providing biological activity data.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Department of ChemistryLucknow UniversityLucknowIndia
  2. 2.Faculty of Biotechnology, Institute of Biosciences and TechnologyShri Ramswaroop Memorial UniversityBarabankiIndia
  3. 3.Department of ChemistryShri Ramswaroop Memorial UniversityBarabankiIndia

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