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Russian Journal of Organic Chemistry

, Volume 55, Issue 6, pp 852–859 | Cite as

Solvent-Free Synthesis, ADME Prediction, and Evaluation of Antibacterial Activity of Novel Sulfonamide Derivatives

  • Z. Rafiee Pour
  • S. M. R. Nazifi
  • A. Afshari Safavi
  • Z. S. Nazifi
  • A. R. MassahEmail author
Review
  • 9 Downloads

Abstract

A series of novel sulfonamides containing a 2-amino-1,3-thiazole fragment have been synthesized using a simple and efficient method under solvent-free conditions. The obtained N-(4-sulfamoyl-1,3-thiazol-2-yl)-4-nitrobenzamides were evaluated for their antibacterial activity against S. aureus and E. coli, and in silico ADME prediction was performed to find biological behavior.

Keywords

sulfonamides 1,3-thiazol-2-amine N-(4-sulfamoyl-1,3-thiazol-2-yl)-4-nitrobenzamides antibacterial activity ADME prediction 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • Z. Rafiee Pour
    • 1
  • S. M. R. Nazifi
    • 2
  • A. Afshari Safavi
    • 3
  • Z. S. Nazifi
    • 1
  • A. R. Massah
    • 1
    • 4
    Email author
  1. 1.Department of Chemistry, Shahreza BranchIslamic Azad UniversityShahreza, IsfahanIran
  2. 2.Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical SciencesIsfahanIran
  3. 3.Student Research Committee, School of HealthIsfahan University of Medical SciencesIsfahanIran
  4. 4.Razi Chemistry Research Center, Shahreza BranchIslamic Azad UniversityShahreza, IsfahanIran

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