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Russian Journal of Organic Chemistry

, Volume 55, Issue 6, pp 796–799 | Cite as

Synthesis and Anticonvulsant Activity of Amino Amides and Amino Esters Based on 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-cyclopentane-1-carboxylic Acid

  • Zh. S. Arustamyan
  • R. E. Markaryan
  • A. A. AghekyanEmail author
  • I. M. Nazaryan
  • A. G. Hakobyan
  • R. G. Paronikyan
  • N. S. Minasyan
Article
  • 8 Downloads

Abstract

Alkaline hydrolysis of 1-(2,3-dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carbonitrile gave the corresponding carboxylic acid which was converted to carbonyl chloride, and the latter reacted with N, N-di-alkylalkane-α,ω-diamines and dialkylaminoalkanols to afford new amino amides and amino esters which were isolated as hydrochlorides. Anticonvulsant activity of the synthesized compounds was studied.

Keywords

1-(2,3-dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carboxylic acid aminoalkylamine amino-alkylalkanol 1,4-benzodioxane amino amide amino ester 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • Zh. S. Arustamyan
    • 1
  • R. E. Markaryan
    • 1
  • A. A. Aghekyan
    • 1
    Email author
  • I. M. Nazaryan
    • 1
  • A. G. Hakobyan
    • 1
  • R. G. Paronikyan
    • 1
  • N. S. Minasyan
    • 2
  1. 1.Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia
  2. 2.Molecular Structure Research Center, Scientific Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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