Russian Journal of Organic Chemistry

, Volume 55, Issue 6, pp 775–781 | Cite as

4-(Het)aryl-4,7-dihydroazolopyrimidines and Their Tuberculostatic Activity

  • Yu. A. TitovaEmail author
  • E. S. Filatova
  • O. V. Fedorova
  • G. L. Rusinov
  • V. N. Charushin


Structural analogs of a promising antituberculous agent, ethyl 5-methyl-7-(thiophen-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate have been synthesized by three-component condensations of various aromatic or hetaromatic aldehydes with several β-dicarbonyl compounds (CH acids) and 1H-1,2,4-triazol-5-amine or 1H-pyrazol-5-amine. The obtained compounds have been evaluated for tuberculostatic activity, and structure-activity relations have been analyzed.


dihydrotriazolopyrimidines dihydropyrazolopyridine multicomponent synthesis tuberculostatic activity 


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The authors thank the Ural Research Institute of Phthisiopulmonology (Yekaterinburg) for performing biological studies in vitro.


This study was performed under financial support by the Russian Science Foundation (project no. 15-13-00077-P).


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • Yu. A. Titova
    • 1
    • 2
    Email author
  • E. S. Filatova
    • 1
  • O. V. Fedorova
    • 1
  • G. L. Rusinov
    • 1
    • 2
  • V. N. Charushin
    • 1
    • 2
  1. 1.Postovskii Institute of Organic Synthesis, Ural BranchRussian Academy of SciencesYekaterinburgRussia
  2. 2.Yeltsin Ural Federal UniversityYekaterinburgRussia

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