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Russian Journal of Organic Chemistry

, Volume 55, Issue 5, pp 721–723 | Cite as

Synthesis of Pyrimido[6,1-a]isoquinolines by the Reaction of Thriethyl Orthoformate with Enamines of 3,3-dialkyl-1,2,3,4-tetrahydroisoquinoline series

  • A. G. MikhailovskiiEmail author
  • D. A. Peretyagin
Short Communications

Abstract

Boiling (Z)-2-[3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides in AcOEt/Ac2O leads involves annelation of the pyrimidine ring to form 6,6-dimethyl-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-2-ones. Similarly, benzo[f]isoquinoline amides form in this reaction 12,12-dialkyl-11,12-dihydro-3H-benzo[f]pyrimido[6,1-a]isoquinolin-3-ones.

Keywords

Z)-2-[3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides benzo[f]isoquinoline amides triethyl orthoformate 6,6-dimethyl-6,7-dihydro-2H-pyrimido[6,1-ia]isoquinolin-2-ones 

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© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Perm State Pharmaceutical AcademyPermRussia

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