Russian Journal of Organic Chemistry

, Volume 55, Issue 1, pp 121–123 | Cite as

Synthesis of New (2-Acetamido)phenylglyoxylamides Containing an Acetal Fragment

  • A. V. BogdanovEmail author
  • A. S. Gazizov
  • A. V. Smolobochkin
  • V. F. Mironov
Short Communications


Mild opening of the five-membered ring in 1-acetylisatins by the action of an equimolar amount of 4,4-diethoxybutan-1-amine afforded 2-(2-acetamidophenyl)-N-(4,4-diethoxybutyl)-2-oxoacetamides in almost quantitative yield.


isatin heterocycles amino acetals glyoxylamides ring opening 


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  1. 1.
    Bogdanov, A.V. and Zaripova, I.F., Chem. Heterocycl. Compd., 2018, vol. 54, p. 686.CrossRefGoogle Scholar
  2. 2.
    Li, H., Cheng, B., Boonnak, N., and Padwa, A., Tetrahedron, 2011, vol. 67, p. 9829.CrossRefGoogle Scholar
  3. 3.
    Nizalapur, Sh., Kimyon, O., Yee, E., Ho, K., Berry, Th., Manefield, M., Cranfield, Ch.G., Willcox, M.D., Black, D.St.C., and Kumar, N., Org. Biomol. Chem., 2017, vol. 15, p. 2033.CrossRefGoogle Scholar
  4. 4.
    Shulga, S.I., Simurova, N.V., Shulga, O.S., and Misa, N.I., Russ. J. Org. Chem., 2014, vol. 50, p. 1175.CrossRefGoogle Scholar
  5. 5.
    Andreani, A., Burnelli, S., Granaiola, M., Leoni, A., Locatelli, A., Morigi, R., Rambaldi, M., Varoli, L., Cremonini, M.A., Placucci, G., Cervellati, R., and Greco, E., Eur. J. Med. Chem., 2010, vol. 45, p. 1374.CrossRefGoogle Scholar
  6. 6.
    Hossain, M.M., Islam, R.M., Saha, S.K., and Islam, M.K., Tetrahedron Lett., 2010, vol. 51, p. 1155.CrossRefGoogle Scholar
  7. 7.
    Cheah, W.Ch., Wood, K., Black, D.St.C., and Kumar, N., Tetrahedron, 2011, vol. 67, p. 7603.CrossRefGoogle Scholar
  8. 8.
    Suryanti, V., Condie, G.C., Bhadbhade, M., Bishop, R., Black, D.St.C., and Kumar, N., Aust. J. Chem., 2014, vol. 67, p. 1270.CrossRefGoogle Scholar
  9. 9.
    Smolobochkin, A.V., Gazizov, A.S., Burilov, A.R., and Pudovik, M.A., Chem. Heterocycl. Compd., 2016, vol. 52, p. 753.CrossRefGoogle Scholar
  10. 10.
    Gazizov, A.S., Burilov, A.R., Pudovik, M.A., and Sinyashin, O.G., Russ. Chem. Rev., 2017, vol. 86, p. 75.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. V. Bogdanov
    • 1
    Email author
  • A. S. Gazizov
    • 1
  • A. V. Smolobochkin
    • 1
  • V. F. Mironov
    • 1
  1. 1.Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific CenterRussian Academy of SciencesKazan, TatarstanRussia

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