Advertisement

Russian Journal of Organic Chemistry

, Volume 55, Issue 1, pp 83–86 | Cite as

Convenient Synthesis of Fluorine-Containing 2-Aryl-5H-[1,3,4]thiadiazolo[3,2-a]quinazolin-5-ones

  • E. V. NosovaEmail author
  • A. D. Poteeva
  • P. A. Slepukhin
Article
  • 3 Downloads

Abstract

An efficient synthetic approach to new fluorine-containing [1,3,4]thiadiazolo[3,2-a]quinazolin-5-ones has been developed on the basis of intramolecular cyclization of N-(N′-benzoylhydrazinecarbothioyl)-benzamides obtained from tetrafluorobenzoyl isothiocyanate and benzohydrazides.

Keywords

fused quinazolines fluorine-containing benzazines hydrazides benzoyl isothiocyanates cyclocondensation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Nosova, E.V., Lipunova, G.N., Charushin, V.N., and Chupakhin, O.N., Fluorosoderzhashchie aziny i benzaziny (Fluorine-Containing Azines and Benzazines), Yekaterinburg: Ural. Otd. Ross. Akad. Nauk, 2011.Google Scholar
  2. 2.
    Hansen, H.C. and Kristiansen, M., US Patent no. 5371080A, 1994.Google Scholar
  3. 3.
    Padia, J.K., Field, M., and Hinton, J., J. Med. Chem., 1998, vol. 41, no. 7, p. 1042.CrossRefGoogle Scholar
  4. 4.
    Ram, V.J., Goel, A., Verma, M., Kaul, I. B., and Kapil, A., Bioorg. Med. Chem. Lett., 1994, vol. 4, no. 17, p. 2087.CrossRefGoogle Scholar
  5. 5.
    Lipunova, G.N., Nosova, E.V., Laeva, A.A., Kodess, M.I., and Charushin, V.N., Russ. J. Org. Chem., 2005, vol. 41, no. 7, p. 1071.CrossRefGoogle Scholar
  6. 6.
    Nosova, E.V., Lipunova, G.N., Laeva, A.A., and Charushin, V.N., Russ. J. Org. Chem., 2005, vol. 41, no. 11, p. 1671.CrossRefGoogle Scholar
  7. 7.
    Shawali, A.S., Abdelhamid, A.O., Hassaneen, H.M., and Shetta, A., J. Heterocycl. Chem., 1982, vol. 19, p. 73.CrossRefGoogle Scholar
  8. 8.
    Shlenev, R.M., Cand. Sci. (Chem.) Dissertation, Ivanovo, 2017.Google Scholar
  9. 9.
    Nosova, E.V., Lipunova, G.N., Laeva, A.A., Sidorova, L.P., and Charushin, V.N., Russ. J. Org. Chem., 2007, vol. 43, p. 68.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • E. V. Nosova
    • 1
    • 2
    Email author
  • A. D. Poteeva
    • 1
  • P. A. Slepukhin
    • 1
    • 2
  1. 1.Yeltsin Ural Federal UniversityYekaterinburgRussia
  2. 2.Postovskii Institute of Organic Synthesis, Ural BranchRussian Academy of SciencesYekaterinburgRussia

Personalised recommendations