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Russian Journal of Organic Chemistry

, Volume 54, Issue 8, pp 1232–1240 | Cite as

Synthesis of 2-[3-Aryl-3-(5-phenylisoxazol-3-yl)propyl] Derivatives of 5,5-Dimethylcyclohexane- and Cyclopenthane-1,3-diones Proceeding from 2-(4-Nitro-3-arylbutyl) Precursors

  • Yu. S. Dontsu
  • F. S. Pashkovskii
  • D. B. Rubinov
  • F. A. Lakhvich
Article
  • 14 Downloads

Abstract

Regiospecific reduction of carbonyl group of acyl chain in the previously described 4-nitro-3-arylbutanoyl derivatives of dimedone and cyclopentane-1,3-dione was performed. On the basis of nitromethyl group of the enol derivatives of the reduction products obtained from the mentioned compounds nitrile oxide intermediates were prepared, which in situ reacted with phenylacetylene to form the corresponding isoxazole derivatives.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Yu. S. Dontsu
    • 1
  • F. S. Pashkovskii
    • 1
  • D. B. Rubinov
    • 1
  • F. A. Lakhvich
    • 1
  1. 1.Institute of Bioorganic Chemistry of Belarus Academy of SciencesMinskBelarus

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