Synthesis of Biaryl Derivatives of Spirofurochromanone in Water and Their Anticancer Activity
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Biaryl derivatives of spirofurochromanones have been synthesised from 4-bromophenyl derivatives of spirofurochromanones upon catalysis by Pd/C in water. Structures of the synthesised compounds are derived from IR, NMR and HRMS spectral data. The compounds have been tested for in vitro cytotoxicity supported by docking studies.
Keywordsspirofurochromanone in vitro cytotoxic activity Suzuki coupling
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We thank The Head, Department of Chemistry, Osmania University, Hyderabad for providing laboratory facilities. We also thank CFRD and IICT analytical team for providing spectral analytical facilities. Prof. D. Ashok is thankful to BSR.
This work was supported by UGC (University Grants Commission) as UGC-MRP, Project sanction letter no. F. 43-211/2014 (SR). New Delhi, and is gratefully acknowledged.
Conflict of Interest
No conflict of interest was declared by the authors.
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