Russian Journal of General Chemistry

, Volume 89, Issue 10, pp 2129–2135 | Cite as

Synthesis of Biaryl Derivatives of Spirofurochromanone in Water and Their Anticancer Activity

  • D. AshokEmail author
  • E. V. L. Madhuri
  • M. Sarasija
  • S. Sree Kanth
  • M. Vijjulatha
  • Akkiraju Anjini Gayatri
  • Someswar Rao Sagurthi
  • N. Sai Krishna


Biaryl derivatives of spirofurochromanones have been synthesised from 4-bromophenyl derivatives of spirofurochromanones upon catalysis by Pd/C in water. Structures of the synthesised compounds are derived from IR, NMR and HRMS spectral data. The compounds have been tested for in vitro cytotoxicity supported by docking studies.


spirofurochromanone in vitro cytotoxic activity Suzuki coupling 


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We thank The Head, Department of Chemistry, Osmania University, Hyderabad for providing laboratory facilities. We also thank CFRD and IICT analytical team for providing spectral analytical facilities. Prof. D. Ashok is thankful to BSR.


This work was supported by UGC (University Grants Commission) as UGC-MRP, Project sanction letter no. F. 43-211/2014 (SR). New Delhi, and is gratefully acknowledged.

Conflict of Interest

No conflict of interest was declared by the authors.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • D. Ashok
    • 1
    Email author
  • E. V. L. Madhuri
    • 1
    • 2
  • M. Sarasija
    • 3
  • S. Sree Kanth
    • 4
    • 7
  • M. Vijjulatha
    • 4
  • Akkiraju Anjini Gayatri
    • 5
  • Someswar Rao Sagurthi
    • 5
  • N. Sai Krishna
    • 6
  1. 1.Green and Medicinal Chemistry Lab, Department of ChemistryOsmania UniversityHyderabadIndia
  2. 2.Department of ChemistryTelangana UniversityNizamabadIndia
  3. 3.Department of ChemistrySatavahana UniversityKarimnagarIndia
  4. 4.Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University, College of ScienceOsmania UniversityHyderabadIndia
  5. 5.Department of Genetics, Drug Design and Molecular Medicine LabOsmania UniversityHyderabadIndia
  6. 6.Analytical DivisionCSIR-IICTHyderabadIndia
  7. 7.Department of Chemistry, Nizam CollegeOsmania UniversityHyderabadIndia

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