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Russian Journal of General Chemistry

, Volume 89, Issue 10, pp 2097–2102 | Cite as

Interaction of Glutathione-Stabilized Gold Nanoclusters with Doxorubicin and Polycation

  • N. P. Iakimov
  • Va. R. Abdullina
  • P. A. Sharanov
  • N. V. Alov
  • V. N. Orlov
  • I. D. Grozdova
  • N. S. Melik-NubarovEmail author
Article
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Abstract

Glutathione-capped gold nanoclusters display polyanionic properties that are manifested in the interaction with cationic species. The nanoclusters form complexes with doxorubicin with effective dissociation constant about 10 µM that increased by an order of magnitude in the presence of 0.15 M NaCl confirming electrostatic character of binding. Adsorption of polylysine arose an increase in the fluorescence of gold nanoclusters due to aggregation induced emission enhancement effect. Fluorescence of the complexes increased several-fold upon addition of up to 1 M of KCl suggesting contribution of non-Coulombic forces in the stabilization of aggregates of gold nanoclusters.

Keywords

gold nanoclusters polyelectrolytes doxorubicin aggregation induced emission enhancement 
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Notes

Funding

The work is performed as a part of the Project “Modern Problems of Chemistry and Physico-chemistry of High Molecular Compounds.”

Conflict of Interest

No conflict of interest was declared by the authors.

Supplementary material

11176_2019_3908_MOESM1_ESM.pdf (128 kb)
Interaction of Glutathione-Stabilized Gold Nanoclusters with Doxorubicin and Polycation

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • N. P. Iakimov
    • 1
  • Va. R. Abdullina
    • 1
  • P. A. Sharanov
    • 1
  • N. V. Alov
    • 1
  • V. N. Orlov
    • 1
  • I. D. Grozdova
    • 1
  • N. S. Melik-Nubarov
    • 1
    Email author
  1. 1.Lomonosov Moscow State UniversityMoscowRussia

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