Interaction of Glutathione-Stabilized Gold Nanoclusters with Doxorubicin and Polycation
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Glutathione-capped gold nanoclusters display polyanionic properties that are manifested in the interaction with cationic species. The nanoclusters form complexes with doxorubicin with effective dissociation constant about 10 µM that increased by an order of magnitude in the presence of 0.15 M NaCl confirming electrostatic character of binding. Adsorption of polylysine arose an increase in the fluorescence of gold nanoclusters due to aggregation induced emission enhancement effect. Fluorescence of the complexes increased several-fold upon addition of up to 1 M of KCl suggesting contribution of non-Coulombic forces in the stabilization of aggregates of gold nanoclusters.
Keywordsgold nanoclusters polyelectrolytes doxorubicin aggregation induced emission enhancement
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The work is performed as a part of the Project “Modern Problems of Chemistry and Physico-chemistry of High Molecular Compounds.”
Conflict of Interest
No conflict of interest was declared by the authors.
- 12.Du, Y., Sheng, H., Astruc, D., and Zhu, M., Chem. Rev., 2019. https://doi.org/10.1021/acs.chemrev.8b00726.