Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1724–1727 | Cite as

N,N-Di(prop-2-yn-1-yl)adamantan-1-amines in 1,3-Dipolar Cycloaddition Reactions with Azide-Containing Pharmacophores

  • V. B. Sokolov
  • A. Yu. AksinenkoEmail author
Letters to the Editor


A synthetic approach to combining pharmacophore ligands with an aminoadamantyl-containing spacer based on a copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of N,N-di(prop-2-yne-1-yl)adamantan-1-amines and azido-containing carbazole, tetrahydrocarbazole, phenothiazine and adamantan-2-amine derivatives was proposed.


N,N-di(prop-2-yn-1-yl)adamantan-1-amines carbazole tetrahydrocarbazole phenothiazine adamantan-2-amine 1,3-dipolar cycloaddition 


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This work was financially supported by the Russian Science Foundation (project no. 14-23-00160-P, synthesis of compounds 9–12) and the Ministry of Education and Science in the framework of the governmental task for 2018 (topic no. 0090-2017-0023).


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© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Institute of Physiologically Active Substances of the Russian Academy of SciencesChernogolovkaRussia

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