Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1718–1723 | Cite as

Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-imidazo[4,5-b]pyridine Derivatives

  • I. S. Murthy
  • R. Sreenivasulu
  • G. Alluraiah
  • R. Ramesh RajuEmail author


A series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized. Structures of the products are supported by 1H and 13C NMR, and mass spectra. All compounds have been tested for their anticancer activity towards four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colon-205 (colon cancer), and A2780 (ovarian cancer). Etoposide was used as a standard drug. The determined IC50 values range from 0.01±0.003 to 23.7±3.72 µM. Among all compounds, six products exhibit the most significant activities.


CCT 129202 carboxyamido triazole imidazo[4,5-b]pyridine 1,2,3-triazol and anticancer activity 


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  1. 1.
    Viktor, O.I., Mkrtchyan, S., Ghazaryan, G., Hakobyan, A., Maalik, A., Supe, L., Villinger, A., Tolmachev, A., Ostrovskyi, D., Vyacheslav, Y.S., Ghochikyan, T.V., and Langer, P., Synthesis, 2011, vol. 3, p. 469. doi Google Scholar
  2. 2.
    George, T., Christopher, J.W., and George, W.W., J. Chem. Soc., Perkin Trans. 1, 1999, p. 629. doi
  3. 3.
    Kirwen, E.M., Batra, T., Karthikeyan, C., Deora, G.S., Rathore, V., Mulakayala, C., Mulakayala, N., Nusbaum, A.C., Chen, J., Amawi, H., McIntosh, K., Shivnath, N., Chowarsia, D., Sharma, N., Arshad, Md., Trivedi, P., and Tiwari, A.K., Acta. Pharm. Sin B, 2017, vol. 7, p. 73. doi CrossRefGoogle Scholar
  4. 4.
    Temple, C., J. Med. Chem., 1990, vol. 33, p. 656. doi CrossRefGoogle Scholar
  5. 5.
    Lavanya, P., Suresh, M., Kotaiah, Y., Harikrishna, N., and Rao, C.V., Asian J. Pharm. Clin. Res., 2011, vol. 4, p. 69.Google Scholar
  6. 6.
    Mader, M., Bioorg. Med. Chem. Lett., 2008, vol. 18, p. 179. doi CrossRefGoogle Scholar
  7. 7.
    Bukowski, L. and Kaliszan, R. Arch. Pharm., 1991, vol. 9, p. 537. doi Google Scholar
  8. 8.
    Chao, S., Oh, S., Um, Y., Jung, J.H., Ham, J., Shin, W.S., and Lee, S., Bioorg. Med. Chem. Lett., 2009, vol. 19, p. 382. doi CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • I. S. Murthy
    • 1
  • R. Sreenivasulu
    • 2
  • G. Alluraiah
    • 3
  • R. Ramesh Raju
    • 1
    Email author
  1. 1.Department of ChemistryAcharya Nagarjuna UniversityNagarjuna NagarIndia
  2. 2.Department of Chemistry, University College of Engineering (Autonomous)Jawaharlal Nehru Technological UniversityKakinadaIndia
  3. 3.Department of ChemistryS V Arts and Science CollegeGiddalurIndia

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