Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-imidazo[4,5-b]pyridine Derivatives
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A series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized. Structures of the products are supported by 1H and 13C NMR, and mass spectra. All compounds have been tested for their anticancer activity towards four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colon-205 (colon cancer), and A2780 (ovarian cancer). Etoposide was used as a standard drug. The determined IC50 values range from 0.01±0.003 to 23.7±3.72 µM. Among all compounds, six products exhibit the most significant activities.
KeywordsCCT 129202 carboxyamido triazole imidazo[4,5-b]pyridine 1,2,3-triazol and anticancer activity
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