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Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1707–1717 | Cite as

Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides

  • R. R. KhattabEmail author
  • A. A. Hassan
  • O. M. Kutkat
  • K. M. Abuzeid
  • N. A. HassanEmail author
Article
  • 24 Downloads

Abstract

A hydrazinylthienopyrimidine derivative reacted with a number of monosaccharides in the presence of a catalytic amount of acetic acid giving the corresponding sugar hydrazones, that undergo oxidative cyclization under the action of ferric chloride with formation of triazolo derivatives. Structures of the products have been elucidated from IR, 1H, and 13C NMR data. Antiviral activity of the newly synthesized compounds is tested against influenza virus H5N1.

Keywords

triazolo derivatives monosaccharides sugar hydrazones C-nucleosides antiviral activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Photochemistry DepartmentNational Research CentreDokki, CairoEgypt
  2. 2.Chemistry Department, Faculty of ScienceUniversity of SuezSuezEgypt
  3. 3.Pharmaceutical Science Department, College of PharmacyShaqra UniversityRiyadhSaudi Arabia
  4. 4.Center of Scientific Excellence for Influenza VirusNational Research CentreDokki, CairoEgypt

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