Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1702–1706 | Cite as

Synthesis, Spectroscopy, and Anticancer Activity of Two New Nanoscale Au(III) N4 Schiff Base Complexes

  • A. M. Naglah
  • M. A. Al-Omar
  • A. Kalmouch
  • A. A. Gobouri
  • S. H. Abdel-Hafez
  • S. M. El-Megharbel
  • M. S. RefatEmail author


Mononuclear Au(III) Schiff base complexes are synthesized by the reaction of 4-aminoantipyrine with hydrazine. The chemical structures of new Schiff bases and their Au(III) complexes are elucidated from their conductance, XRD, and spectroscopic (IR, UV-Vis, 1H, and 13C NMR) data. Au(III) Ion is coordinated with the synthesized Schiff bases via four nitrogen atoms of the antipyrine and azomethine groups. Au(III) Complexes are electrolytes with three uncoordinated Cl ions, and have a square planar geometry. Their morphology is characterized by SEM and TEM methods. Cytotoxic effect of the complexes is tested against human breast cancer (MCF-7) and hepatocellular carcinoma (HepG-2) cell lines.


Schiff base aminoantipyrine gold complexes TEM nanoparticles spectroscopy 


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The authors are grateful to the Deanship of Scientific Research, king Saud University for funding through Vice Deanship of Scientific Research Chairs.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. M. Naglah
    • 1
    • 2
  • M. A. Al-Omar
    • 1
  • A. Kalmouch
    • 2
  • A. A. Gobouri
    • 3
  • S. H. Abdel-Hafez
    • 3
    • 4
  • S. M. El-Megharbel
    • 3
    • 5
  • M. S. Refat
    • 3
    • 6
    Email author
  1. 1.Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Peptide Chemistry Department, Chemical Industries Research DivisionNational Research CentreDokki, CairoEgypt
  3. 3.Chemistry Department, Faculty of ScienceTaif UniversityTaifSaudi Arabia
  4. 4.Chemistry Department, Faculty of ScienceAssiut UniversityAssiutEgypt
  5. 5.Chemistry Department, Faculty of ScienceZagazig UniversityZagazigEgypt
  6. 6.Department of Chemistry, Faculty of SciencePort Said UniversityPort SaidEgypt

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