Advertisement

Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1702–1706 | Cite as

Synthesis, Spectroscopy, and Anticancer Activity of Two New Nanoscale Au(III) N4 Schiff Base Complexes

  • A. M. Naglah
  • M. A. Al-Omar
  • A. Kalmouch
  • A. A. Gobouri
  • S. H. Abdel-Hafez
  • S. M. El-Megharbel
  • M. S. RefatEmail author
Article
  • 7 Downloads

Abstract

Mononuclear Au(III) Schiff base complexes are synthesized by the reaction of 4-aminoantipyrine with hydrazine. The chemical structures of new Schiff bases and their Au(III) complexes are elucidated from their conductance, XRD, and spectroscopic (IR, UV-Vis, 1H, and 13C NMR) data. Au(III) Ion is coordinated with the synthesized Schiff bases via four nitrogen atoms of the antipyrine and azomethine groups. Au(III) Complexes are electrolytes with three uncoordinated Cl ions, and have a square planar geometry. Their morphology is characterized by SEM and TEM methods. Cytotoxic effect of the complexes is tested against human breast cancer (MCF-7) and hepatocellular carcinoma (HepG-2) cell lines.

Keywords

Schiff base aminoantipyrine gold complexes TEM nanoparticles spectroscopy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

Acknowledgments

The authors are grateful to the Deanship of Scientific Research, king Saud University for funding through Vice Deanship of Scientific Research Chairs.

References

  1. 1.
    Teng, Y., Liu, R., Li, C., and Zhang, H., J. Hazard. Mater., 2011, vol. 192, p. 1766. doi  https://doi.org/10.1016/j.jhazmat.2011.07.012 CrossRefGoogle Scholar
  2. 2.
    Bernardo, K., Leppard, S., Robert, A., Cummenges, G., Dehan, F., and Meunier, B., Inorg. Chem., 1996, vol. 35, p. 387. doi  https://doi.org/10.1021/ic950700i CrossRefGoogle Scholar
  3. 3.
    Joseph, J., Nagashri, K., Ayisha, G., and Rani, B., J. Saudi Chem. Soc., 2013, vol. 17, p. 285. doi  https://doi.org/10.1016/j.jscs.2011.04.007 CrossRefGoogle Scholar
  4. 4.
    Hodnett, E.M. and Dunn, W.J., J. Med. Chem., 1972, vol. 15, p. 339. doi  https://doi.org/10.1021/jm00273a037 CrossRefGoogle Scholar
  5. 5.
    Mosmann, T., J. Immunol. Methods, 1983, vol. 55, p. 65. doi  https://doi.org/10.1016/0022-1759(83)90303-4 Google Scholar
  6. 6.
    Gangadevi, V. and Muthumary, J., Afr. J. Biotechnol., 2007, vol. 6, p. 1382.Google Scholar
  7. 7.
    Refat, M.S., J. Mol. Struct., 2007, vol. 842, p. 24. doi  https://doi.org/10.1016/j.molstruc.2006.12.006 CrossRefGoogle Scholar
  8. 8.
    Abdalrazaq, E.A., Buttrus, N.H., and Abd Al-Rahman, A.A., Asian J. Chem., 2010, vol. 22, p. 2179.Google Scholar
  9. 9.
    Tunney, J.M., Blake, A.J., Davies, E.S., Mcmater, J., Wilson, C., and Garner, C.D., Polyhedron, 2006, vol. 25, p. 591. doi  https://doi.org/10.1016/j.poly.2005.09.002 CrossRefGoogle Scholar
  10. 10.
    Cullity, B.D., Elements of X-Ray Diffraction, Addison-Wesley, Reading, MA, 1972, p. 102.Google Scholar
  11. 11.
    Velumani, S., Mathew, X., and Sebastian, P.J., Solar Energy Mater. Solar Cells, 2003, vol. 76, p. 359. doi  https://doi.org/10.1016/S0927-0248(02)00288-X CrossRefGoogle Scholar
  12. 12.
    Zhang, Y., Wei, S., and Chen, S., Int. J. Electrochem. Sci., 2013, vol. 8, p. 6493.Google Scholar
  13. 13.
    Shi, W., Casas, J., Venkataramasubramani, M., and Tang, L., Int. Scholar. Res. Network ISRN Nanomater., 2012.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. M. Naglah
    • 1
    • 2
  • M. A. Al-Omar
    • 1
  • A. Kalmouch
    • 2
  • A. A. Gobouri
    • 3
  • S. H. Abdel-Hafez
    • 3
    • 4
  • S. M. El-Megharbel
    • 3
    • 5
  • M. S. Refat
    • 3
    • 6
    Email author
  1. 1.Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Peptide Chemistry Department, Chemical Industries Research DivisionNational Research CentreDokki, CairoEgypt
  3. 3.Chemistry Department, Faculty of ScienceTaif UniversityTaifSaudi Arabia
  4. 4.Chemistry Department, Faculty of ScienceAssiut UniversityAssiutEgypt
  5. 5.Chemistry Department, Faculty of ScienceZagazig UniversityZagazigEgypt
  6. 6.Department of Chemistry, Faculty of SciencePort Said UniversityPort SaidEgypt

Personalised recommendations