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Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1696–1701 | Cite as

Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole

  • D. G. S. SudhakarEmail author
  • A. Srinivasa Rao
  • Ch. Venkata Ramana Reddy
Article
  • 3 Downloads

Abstract

A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by 1H and 13C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity.

Keywords

Cefozopram KC 12291 ataluren anticancer activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • D. G. S. Sudhakar
    • 1
    • 2
    Email author
  • A. Srinivasa Rao
    • 1
  • Ch. Venkata Ramana Reddy
    • 2
  1. 1.Medicinal Chemistry DivisionGVK Biosciences Private LimitedHyderabadIndia
  2. 2.Department of ChemistryJawaharlal Nehru Technological University, Hyderabad, KukatpallyHyderabadIndia

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