Synthesis and Antibacterial Evaluation of Cu(II), Co(II), and Mn(II) Complexes with Schiff Bases Derived from 5-Aminosalicylic Acid and o-Vanillin
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The current study is devoted to the synthesis of Schiff base ligand, HL, by condensation of 5-aminosalicylic acid with o-vanillin, followed by preparing its Cu(II), Co(II), Mn(II), and Zn(II) complexes, and their characterization. The Schiff base behaves as a bidentate ligand which forms tetrahedral complexes with Cu(II) and Zn(II), unlike Co(II) and Mn(II) that give octahedral complexes. The Schiff base ligand and its complexes with Cu2+, Co2+, Mn2+, and Zn2+ exhibit considerable antibacterial activity against some drug resistant reference strains and local isolates of S. aureus, E. Coli, P. aersginosa. Overall, the metal complexes exhibit more potent antibacterial activity than the ligand HL alone.
KeywordsSchiff bases condensation of aldehydes metal complexes XRD analysis antibacterial activity
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Funding in the Lu lab was provided by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (no. 2012-28, Fundamental Research Funds for the Central Universities (15D110508, 15D110527, 13D110522, 17D210502, 17D310512, 18D210501, 18D310507, 2232014D3-39), the National College Student Innovation Experiment Program (14T10501, 105-03-0178028). Funding in the Saleem lab was provided by the Higher Education Commission of Pakistan for Project Grant no. 2013-85/R&D/09-Metal complexes as anticancer agents. The project was funded by HEC, Pakisatn vide project no. NRPU/R&D’dHEC/14/535.
- 7.Niu, M.-J., Li, Z., Chang, G.-L., Kong, X.-J., Hong, M., and Zhang, Q.-F., PLoS One, 2015, vol. 10, no. 6. doi https://doi.org/10.1371/journal.pone.0130922