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Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1691–1695 | Cite as

Synthesis and Antibacterial Evaluation of Cu(II), Co(II), and Mn(II) Complexes with Schiff Bases Derived from 5-Aminosalicylic Acid and o-Vanillin

  • M. A. ShaheenEmail author
  • W. Xiao
  • M. Aziz
  • A. Karim
  • M. Saleem
  • M. Mustaqeem
  • T. Mehmood
  • M. N. Tahir
  • A. Sultan
  • A. Simair
  • C. LuEmail author
Article
  • 8 Downloads

Abstract

The current study is devoted to the synthesis of Schiff base ligand, HL, by condensation of 5-aminosalicylic acid with o-vanillin, followed by preparing its Cu(II), Co(II), Mn(II), and Zn(II) complexes, and their characterization. The Schiff base behaves as a bidentate ligand which forms tetrahedral complexes with Cu(II) and Zn(II), unlike Co(II) and Mn(II) that give octahedral complexes. The Schiff base ligand and its complexes with Cu2+, Co2+, Mn2+, and Zn2+ exhibit considerable antibacterial activity against some drug resistant reference strains and local isolates of S. aureus, E. Coli, P. aersginosa. Overall, the metal complexes exhibit more potent antibacterial activity than the ligand HL alone.

Keywords

Schiff bases condensation of aldehydes metal complexes XRD analysis antibacterial activity 

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Notes

Funding

Funding in the Lu lab was provided by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (no. 2012-28, Fundamental Research Funds for the Central Universities (15D110508, 15D110527, 13D110522, 17D210502, 17D310512, 18D210501, 18D310507, 2232014D3-39), the National College Student Innovation Experiment Program (14T10501, 105-03-0178028). Funding in the Saleem lab was provided by the Higher Education Commission of Pakistan for Project Grant no. 2013-85/R&D/09-Metal complexes as anticancer agents. The project was funded by HEC, Pakisatn vide project no. NRPU/R&D’dHEC/14/535.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • M. A. Shaheen
    • 1
    • 2
    Email author
  • W. Xiao
    • 1
  • M. Aziz
    • 2
  • A. Karim
    • 2
  • M. Saleem
    • 2
  • M. Mustaqeem
    • 2
  • T. Mehmood
    • 3
  • M. N. Tahir
    • 4
  • A. Sultan
    • 5
  • A. Simair
    • 1
  • C. Lu
    • 1
    Email author
  1. 1.Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and BiotechnologyDonghua UniversityShanghaiChina
  2. 2.Department of ChemistryUniversity of SargodhaSargodhaPakistan
  3. 3.Institute of Biochemistry and BiotechnologyUniversity of Veterinary and Animal SciencesLahorePakistan
  4. 4.Department of PhysicsUniversity of SargodhaSargodhaPakistan
  5. 5.Department of Chemistry, Division of Science and TechnologyUniversity of EducationLahorePakistan

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