Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1673–1682 | Cite as

Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives

  • M. N. M. YousifEmail author
  • I. F. Nassar
  • N. M. Yousif
  • H. M. Awad
  • W. A. El-SayedEmail author


New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.


piperidinone pyrimidine thiazolopyrimidine diazipine oxatriazine thiazole anticancer HCT-116 MCF-7 


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Photochemistry DepartmentNational Research CentreCairoEgypt
  2. 2.Faculty of Specific EducationAin Shams UniversityCairoEgypt
  3. 3.Tanning Materials and Leather Technology DepartmentNational Research CentreDokki, CairoEgypt
  4. 4.Chemistry Department, Faculty of ScienceQassim UniversityBuraydahSaudi Arabia

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