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Russian Journal of General Chemistry

, Volume 89, Issue 8, pp 1591–1594 | Cite as

Synthesis and Fungicidal Activity of Bis-1,5,3-dithiazepanes and Crown-Like Macroheterocycles

  • E. B. RakhimovaEmail author
  • R. A. Ismagilov
  • A. G. Ibragimov
Article
  • 6 Downloads

Abstract

An efficient method was developed for the synthesis of bis-1,5,3-dithiazepanes and crown-like N-cycloalkyl-1,11-dioxa-4,8-dithia-6-azacyclotridecanes by heterocyclization of cyclohexane-substituted diamines and carbocyclic primary amines with N, N, N1, N1-tetramethylmethanediamine and aliphatic α,ω-dithiols using SmCl3-6H2O as a catalyst. Fungicidal activity of 1,3-bis[(1,5,3-dithiazepan-3-yl)methyl]cyclohexane and 6-cyclopropyl-1,11-dioxa-4,8-dithia-6-azacyclotridecane in relation to Rhizoctonia solani and Candida albicans strains was revealed.

Keywords

catalysis heterocyclization 1,5,3-dithiazepanes 1,11-dioxa-4,8-dithia-6-azacyclotridecanes fungicidal activity 

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Notes

Acknowledgments

The authors are grateful to N.F. Galimzyanova (Institute of Biology, Ufa Federal Research Center of the Russian Academy of Sciences) for conducting studies on fungicidal activity, and to the University of Queensland (Australia) for primary antimicrobial screening.

Funding

This work was performed in accordance with the research plans of the Institute of Petrochemistry and Catalysis of the Russian Academy of Sciences by the topic “Metal-complex and heterogeneous catalysis in the construction of macroheterocycles and heteroatomic compounds” (state registration number AAAA-A19-119022290010-9, 2019-2021) using the equipment of the Center for collective use “Agidel.”

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • E. B. Rakhimova
    • 1
    Email author
  • R. A. Ismagilov
    • 1
  • A. G. Ibragimov
    • 1
  1. 1.Institute of Petrochemistry and Catalysis of the Russian Academy of SciencesUfaRussia

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