Russian Journal of General Chemistry

, Volume 89, Issue 7, pp 1535–1540 | Cite as

Microwave Assisted Synthesis and Antimicrobial Activity of Novel 1,3,4-Thiadiazoles and 1,2,4-Triazoles Derived from 2-(3-Fluorophenyl)-4-methylthiazole-5-carbohydrazide

  • S. G. Dengale
  • B. K. Karale
  • H. N. Akolkar
  • N. R. Darekar
  • K. K. DeshmukhEmail author


The precursors 2-{[2-(3-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}-N-phenylhydrazinecarbothioamides are synthesized from 2-(3-fluorophenyl)-4-methylthiazole-5-carbohydrazide and aryl isothiocyanates. MW irradiation of the precursors under alkali or acidic conditions led to the products of cyclization 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-N-phenyl-1,3,4-thiadiazol-2-amine or 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-4-phenyl-4H-1,2,4-triazole-3-triiol, accordingly. Structures of the synthesized compounds are confirmed by IR, 1H, and 13C NMR, and mass spectra. All products are tested in vitro for their antibacterial and antifungal activity.


thiazole 1,3,4-thiadiazole 1,2,4-triazole antimicrobial activity 


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Authors are thankful to Department of Science and Technology, New Delhi for providing research facilities through FIST scheme and SAIF, Panjab University, Chandigarh for providing spectral facilities.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • S. G. Dengale
    • 1
  • B. K. Karale
    • 2
  • H. N. Akolkar
    • 2
  • N. R. Darekar
    • 2
  • K. K. Deshmukh
    • 1
    Email author
  1. 1.P.G. and Research, Department of Chemistry, Sangamner Nagarpalika ArtsD. J. Malpani Commerce and B.N. Sarada Science CollegeSangamnerIndia
  2. 2.P.G. and Research, Department of ChemistryRadhabai Kale Mahila MahavidyalayaAhmednagarIndia

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