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Russian Journal of General Chemistry

, Volume 89, Issue 7, pp 1485–1490 | Cite as

Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives

  • T. Yakantham
  • R. Sreenivasulu
  • R. R. RajuEmail author
Article
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Abstract

A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.

Keywords

dasatinib proxazole 1,2,4-oxadiazole anticancer activity MTT assay 

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© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Department of ChemistryAcharya Nagarjuna UniversityNagarjuna NagarIndia
  2. 2.Department of ChemistryUniversity College of Engineering (Autonomous), Jawaharlal Nehru Technological UniversityKakinadaIndia

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