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Russian Journal of General Chemistry

, Volume 89, Issue 6, pp 1202–1208 | Cite as

Synthesis, Characterization, Molecular Docking, and Antimicrobial Activity of New Arylidene-Substituted Imidazoles

  • Y. Aparna
  • L. N. SharadaEmail author
  • N. J. P. Subhashini
  • Sivan Sreekanth
Article
  • 3 Downloads

Abstract

The title compounds are synthesized by condensation of 2-[4-(arylidene)-5-oxo-4, 5-dihydrooxazol-2-yl]phenylacetate with aromatic amines in presence of the Vilsemeier Haack reagent. Structures of all compounds are elucidated from 1H and 13C NMR, IR, and mass spectra. The compounds are tested for their antibacterial activity. Molecular docking study is focused on the relative orientation and nature of bonding between imidazoles and bacterial protein.

Keywords

O-hydroxybenzoyl glycine Vilsmeier Haack reagent zeolite imidazoles antimicrobial activity molecular docking 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • Y. Aparna
    • 1
  • L. N. Sharada
    • 1
    Email author
  • N. J. P. Subhashini
    • 1
  • Sivan Sreekanth
    • 1
  1. 1.Department of ChemistryUniversity College of Science, Osmania UniversityHyderabad, TelanganaIndia

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