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Russian Journal of General Chemistry

, Volume 89, Issue 6, pp 1169–1176 | Cite as

Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives

  • V. L. GeinEmail author
  • A. N. Yankin
  • N. V. Nosova
  • E. B. Levandovskaya
  • V. V. Novikova
  • I. P. Rudakova
Article
  • 3 Downloads

Abstract

Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities

Keywords

indazoles hydrazones hydrazine hydrate phenylhydrazine antimicrobial activity anti-inflammatory activity 

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Copyright information

© Pleiades Publishing, Ltd 2019

Authors and Affiliations

  • V. L. Gein
    • 1
    Email author
  • A. N. Yankin
    • 2
  • N. V. Nosova
    • 1
  • E. B. Levandovskaya
    • 1
  • V. V. Novikova
    • 1
  • I. P. Rudakova
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.St. Petersburg State UniversitySt. PetersburgRussia

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