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Russian Journal of General Chemistry

, Volume 89, Issue 2, pp 364–367 | Cite as

Methyl Trifluoropyruvate Pyrazin-2-ylimine in Cyclocondensation and Cycloaddition Reactions

  • V. B. Sokolov
  • A. Yu. AksinenkoEmail author
Letters to the Editor
  • 7 Downloads

Abstract

The transformations of methyl trifluoropyruvate pyrazin-2-ylimine in the cyclocondensation reactions with 2-aminothiazoline, amidines, aminocrotonitrile and aza-Diels—Alder reactions with cyanamines, leading to five- and six-membered trifluoromethyl-containing heterocycles, were studied. The possibility of using 4-(pyrazin-2-ylamino)-1-(prop-2-yn-1-yl)-4-(trifluoromethyl)-1H-imidazol-5(4H)-one, the product of methyl trifluoropyruvate pyrazin-2-ylimine cyclocondensation, for modification of phenothiazine by copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition was shown.

Keywords

methyl trifluoropyruvate pyrazin-2-ylimine 2-aminothiazoline benzamidines aminocrotonitrile cyanamines phenothiazine aza-Diels—Alder reaction 1,3-dipolar cycloaddition 

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© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Institute of Physiologically Active Compounds of the Russian Academy of SciencesChernogolovkaRussia

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