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Russian Journal of General Chemistry

, Volume 89, Issue 2, pp 357–363 | Cite as

Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

  • A. H. Ahmed
  • A. Ebead
  • H. Afifi
  • A. A.-H. Abdel-RahmanEmail author
Article

Abstract

New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.

Keywords

hydantoin 2-thiohydantoin 1,2,3-benzotriazole antitumor activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. H. Ahmed
    • 1
  • A. Ebead
    • 2
  • H. Afifi
    • 3
  • A. A.-H. Abdel-Rahman
    • 4
    Email author
  1. 1.Chemistry Department, Faculty of Medicinal ScienceUniversity of Science and TecnologyTaeezYemen
  2. 2.Chemistry Department, Faculty of ScienceArish UniversityCairoEgypt
  3. 3.Faculty of Industrial EducationBeni Suef UniversityBeni SuefEgypt
  4. 4.Chemistry Department, Faculty of ScienceMenoufia UniversityShebin El-KomEgypt

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