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Russian Journal of General Chemistry

, Volume 89, Issue 1, pp 151–152 | Cite as

Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide

  • A. V. Baklykov
  • G. L. Rusinov
  • V. L. Rusinov
  • V. N. Charushin
  • D. S. Kopchuk
  • G. V. ZyryanovEmail author
  • G. A. Artem’ev
Letters to the Editor
  • 4 Downloads

Abstract

5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3H-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl2 in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.

Keywords

5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one supercritical carbon dioxide solvent-free synthesis 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. V. Baklykov
    • 1
    • 2
  • G. L. Rusinov
    • 1
    • 2
  • V. L. Rusinov
    • 1
    • 2
  • V. N. Charushin
    • 1
    • 2
  • D. S. Kopchuk
    • 1
    • 2
  • G. V. Zyryanov
    • 1
    • 2
    Email author
  • G. A. Artem’ev
    • 1
  1. 1.Postovskii Institute of Organic Synthesis, Ural BranchRussian Academy of SciencesYekaterinburgRussia
  2. 2.Yeltsin Ural Federal UniversityYekaterinburgRussia

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