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Russian Journal of General Chemistry

, Volume 89, Issue 1, pp 142–147 | Cite as

Selective Complexation of Hydrazone Based Ketimine with 3d, 4d, and 5d Metals: Synthesis, Characterization, and Biological Activity

  • F. Ahmad
  • M. B. TajEmail author
  • S. A. Tirmizi
  • W. Alelwani
  • D. Hajjar
  • A. A. Makki
  • S. Shah
  • U. Ali
  • U. Hassan
  • M. Tahir
  • S. Siddiq
Article
  • 6 Downloads

Abstract

The hydrazone derived ketimine of dehydroacetic acid and its metal {Cu(II), Ni(II), Zn(II), Fe(III), Cd(II), Pd(II), La(III), Nd(III), Ce(III)} complexes are synthesized and characterized by IR, 1H and 13C NMR, and UV-Vis spectroscopy. DNA studies have been carried out for metal complexes by electronic absorption spectroscopy. It is determined that metal complexes bind to DNA through intercalation. The complexes of Cu(II), Zn(II) and Pd(II) demonstrate significant activity against HeLa cells (cervical cancer).

Keywords

ketimine complexes electronic spectroscopy enzymatic inhibition anti-cancer activity DNA interaction 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • F. Ahmad
    • 1
  • M. B. Taj
    • 2
    Email author
  • S. A. Tirmizi
    • 1
  • W. Alelwani
    • 3
  • D. Hajjar
    • 3
  • A. A. Makki
    • 3
  • S. Shah
    • 1
  • U. Ali
    • 1
  • U. Hassan
    • 1
  • M. Tahir
    • 1
  • S. Siddiq
    • 4
  1. 1.Department of ChemistryQuaid-e-Azam University IslamabadIslamabadPakistan
  2. 2.Department of ChemistryIslamia University BahawalpurIslamabadPakistan
  3. 3.Department of Biochemistry, Faculty of ScienceUniversity of JeddahSaudi ArabiaPakistan
  4. 4.HEJ Research Institute KarachiIslamabadPakistan

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