Advertisement

Russian Journal of General Chemistry

, Volume 89, Issue 1, pp 63–66 | Cite as

Synthesis and Properties of [4-(Diethylamino)phenyl]dichlorophosphine

  • M. B. GazizovEmail author
  • Sh. N. Ibragimov
  • O. D. Khairullina
  • S. Yu. Ivanova
  • K. S. Gazizova
  • R. A. Khairullin
  • Yu. S. Kirillina
  • A. L. Pistsova
Article
  • 6 Downloads

Abstract

[4-(Diethylamino)phenyl]dichlorophosphine synthesized for the first time has reacted with trialkyl orthoformate and ethylene oxide in the presence of ethyl chloroacetate with the formation of phosphorylated formals and ethyl [4-(diethylamino)phenyl](2-chloroethoxy)phosphonyl acetate, a precursor of a new analog of nootropic drug KAPAKh.

Keywords

[4-(diethylamino)phenyl]dichlorophosphine trialkyl orthoformates phosphorylated formal ethyl [4-(diethylamino)phenyl](2-chloroethoxy)phosphonyl acetate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bourneuf, M., Bull. Soc. Chim. France, 1923, vol. 33, p. 1808.Google Scholar
  2. 2.
    Raundnitz, H., Ber., 1927, vol. 60, p. 743.Google Scholar
  3. 3.
    Purdela, D. and Vilceanu, R., Chimia compușilor organici ai fosforului și ai acizilor lui, Editura Academiei Republicii Socialiste Romania, 1965.Google Scholar
  4. 4.
    Semina, I.G., Semina, I.I., Faizyllin, D.A., Baichurina, N.A., Stupishina, E.A., Vylegzhanina, N.N., Tarasova, R.I., Fedotov, V.D., Garaev, R.S., and Pavlov, V.A., Bull. Exp. Biol. Med., 1998, vol. 126, no. 8, p. 175. doi  https://doi.org/10.1007/BF02446913 Google Scholar
  5. 5.
    Semina, I.I., Tikhonova, N.A., Baychurina, A.Z., Tarasova, R.I., Pavlov, V.A., Garaev, R.S., and Shilovskaya, E.V., Vestn. Ross. Akad. Med. Nauk, 1999, no. 3, p. 32.Google Scholar
  6. 6.
    Tarasova, R.I., Semina, I.I., Pavlov, V.A., and Moskva, V.V., RF Patent 214961, 1999; Byull. Izobret., 2000. no. 33.Google Scholar
  7. 7.
    Zimakov, P.V., Diment, O.N., Bogoslovskii, N.A., Vaisberg, F.I., Stepanov, Yu.N., Kolchina, N.A., Kazarnovskaya, R.Sh., Sokolova, V.A., Kozlova, Yu.A., Vol’, Yu.Ts., and Shishakov, N.A., Okis’ etilena (Ethylene Oxide), Moscow: Khimiya, 1967.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • M. B. Gazizov
    • 1
    Email author
  • Sh. N. Ibragimov
    • 1
  • O. D. Khairullina
    • 1
  • S. Yu. Ivanova
    • 1
  • K. S. Gazizova
    • 1
  • R. A. Khairullin
    • 1
  • Yu. S. Kirillina
    • 1
  • A. L. Pistsova
    • 1
  1. 1.Kazan National Research Technological UniversityKazan, TatarstanRussia

Personalised recommendations