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Russian Journal of General Chemistry

, Volume 88, Issue 13, pp 2934–2936 | Cite as

Stereoselective Bioreduction of Hexan-2-one into (2S)-(+)-Hexan-2-ol

  • A. R. ChanyshevaEmail author
  • E. A. Sheiko
  • V. V. Zorin
Article
  • 5 Downloads

Abstract

A method for the synthesis of (2S)-(+)-hexan-2-ol, the precursor of a series of drugs, by the enantioselective bioreduction of the prochiral hexan-2-one is proposed. The use of various exogenous reducing agents (isopropanol, ethanol, and glucose) for increasing the yield of the target (2S)-(+)-hexan-2-ol and the enantioselectivity of the bioreduction of hexane-2-one are investigated.

Keywords

bioreduction enantioselective biocatalysis hexan-2-one (2S)-(+)-hexan-2-ol 

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Copyright information

© Pleiades Publishing, Ltd 2019

Authors and Affiliations

  • A. R. Chanysheva
    • 1
    Email author
  • E. A. Sheiko
    • 1
  • V. V. Zorin
    • 1
  1. 1.Ufa State Petroleum Technological UniversityUfa, BashkortostanRussia

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