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Russian Journal of General Chemistry

, Volume 88, Issue 11, pp 2425–2431 | Cite as

Facile Synthesis of N-Phenyl Benzamidine Derivatives, Their Skin Protecting, and Anti-Aging Activity

  • M. B. TajEmail author
  • S. A. Tirmizi
  • A. Raheel
  • W. Alelwani
  • D. Hajjar
  • A. A. Makki
  • U. Ali
  • M. Darroudi
  • H. B. M. Ali
Article
  • 11 Downloads

Abstract

The straight forwarded new green approach to the synthesis of N-phenyl benzamidine derivatives catalyzed by copper oxide nanoparticles (CuOnp) under solvent-free conditions (without microwave radiations and with MW radiation) is presented. All synthesized compounds 3a–3k are characterized by FT-IR, NMR, and single crystal XRD analysis and tested for their antioxidant and elastase inhibition activities. The compounds 3i and 3j demonstrate significant free radical scavenging activity. The accumulated data indicate that some synthesized compounds can be recognized as good anti-aging agents.

Keywords

N-phenyl benzamidine SFRC MW radiations antioxidant activity elastase inhibition 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • M. B. Taj
    • 1
    • 4
    Email author
  • S. A. Tirmizi
    • 1
  • A. Raheel
    • 1
  • W. Alelwani
    • 2
  • D. Hajjar
    • 2
  • A. A. Makki
    • 2
  • U. Ali
    • 1
  • M. Darroudi
    • 3
  • H. B. M. Ali
    • 4
  1. 1.Department of ChemistryQuaid-e-Azam UniversityIslamabadPakistan
  2. 2.Department of Biochemistry, Faculty of ScienceUniversity of JeddahJeddahSaudi Arabia
  3. 3.Faculty of ChemistryUniversity of MazandaranBabolsarIran
  4. 4.Department of ChemistryUniversity of MalayaKualalampurMalaysia

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