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Russian Journal of General Chemistry

, Volume 88, Issue 11, pp 2354–2358 | Cite as

Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives

  • E. A. PopovaEmail author
  • O. V. Mikolaichuk
  • A. V. Protas
  • A. V. Mukhametshina
  • G. K. Ovsepyan
  • G. L. Starova
  • R. V. Suezov
  • A. V. Fonin
  • R. E. Trifonov
Article
  • 23 Downloads

Abstract

A series of trans-palladium(II) complexes (trans-[PdCl2L2], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by 1H and 13C–{1H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.

Keywords

tetrazole-containing Pd(II) complexes tetrazol-2-ylacetic acid derivatives interaction with DNA antiproliferative activity 

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References

  1. 1.
    Johnstone, T.C., Suntharalingam, K., and Lippard, S.J., Chem. Rev., 2016, vol. 116, no. 5, p. 3436. doi 10.1021/acs.chemrev.5b00597CrossRefGoogle Scholar
  2. 2.
    Fanelli, M., Formica, M., Fusi, V., Giorgi, L., Micheloni, M., and Paoli, P., Coord. Chem. Rev., 2016, vol. 310, p. 41. doi 10.1016/j.ccr.2015.11.004CrossRefGoogle Scholar
  3. 3.
    Huq, F., Yu, J.Q., and Beale, P., Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy, Totowa: Humana Press, 2009, p.11.CrossRefGoogle Scholar
  4. 4.
    Popova, E.A., Trifonov, R.E., and Ostrovskii, V.A., Arkivoc, 2012, part (i), p. 45. doi 10.3998/ark.5550190.0013.102Google Scholar
  5. 5.
    Ostrovskii, V.A., Popova, E.A., and Trifonov, R.E., Advances in Heterocyclic Chemistry, Scriven, E.F.V., and Ramsden, C.A., Eds., Cambridge: Academic, 2017, vol. 123, p. 1. doi 10.1016/bs.aihch.2016.12.003CrossRefGoogle Scholar
  6. 6.
    Popova, E.A., Protas, A.V., and Trifonov, R.E., Anticancer Agents Med. Chem., 2017, vol. 17, no. 14, p. 1856. doi 10.2174/1871520617666170327143148Google Scholar
  7. 7.
    Popova, E.A., Serebryanskaya, T.V., Selivanov, S.I., Haukka, M., Panikorovsky, T.L., Gurzhiy, V.V., Ott, I., Trifonov, R.E., and Kukushkin, V.Y., Eur. J. Inorg. Chem., 2016, p. 4659. doi 10.1002/ejic.201600626Google Scholar
  8. 8.
    Protas, A.V., Popova, E.A., Suslonov, V.V., and Trifonov, R.E., Polyhedron, 2017, vol. 124, p. 131. doi 10.1016/j.poly.2016.12.032CrossRefGoogle Scholar
  9. 9.
    Protas, A.V., Popova, E.A., Mikolaichuk, O.V., Porozov, Yu.B., Mehtiev, A.R., Ott, I., Alekseev, G.V., Kasyanenko, N.A., and Trifonov, R.E., Inorg. Chim. Acta, 2018, vol. 473, p. 133. doi 10.1016/j.ica.2017.12.040CrossRefGoogle Scholar
  10. 10.
    Topala, T., Bodoki, A., Oprean, L., and Oprean, R., Farmacia, 2014, vol. 62, no. 6, p. 1049.Google Scholar
  11. 11.
    Keene, F.R., Smith, J.A., and Collins, J.G., Coord. Chem. Rev., 2009, vol. 253, nos. 15–16, p. 2021. doi 10.1016/j.ccr.2009.01.004CrossRefGoogle Scholar
  12. 12.
    Kathiresan, S., Mugesh, S., Murugan, M., Ahamed, F., and Annaraj, J., RSC Adv., 2016, vol. 6, no. 3, p. 1810. doi 10.1039/C5RA20607CCrossRefGoogle Scholar
  13. 13.
    Ramakrishnan, S. and Palaniandavar, M., J. Chem. Sci., 2005, vol. 117, no. 2, p. 179. doi 10.1007/BF03356114CrossRefGoogle Scholar
  14. 14.
    Roy, S., Westmaas, J.A., Hagen, K.D., Wezel, G.P., and Reedijk, J., J. Inorg. Biochem., 2009, vol. 103, no. 9, p. 1288. doi 10.1016/j.jinorgbio.2009.07.003CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • E. A. Popova
    • 1
    Email author
  • O. V. Mikolaichuk
    • 1
  • A. V. Protas
    • 1
  • A. V. Mukhametshina
    • 1
  • G. K. Ovsepyan
    • 1
  • G. L. Starova
    • 1
  • R. V. Suezov
    • 2
    • 3
  • A. V. Fonin
    • 3
  • R. E. Trifonov
    • 1
    • 2
  1. 1.St. Petersburg State UniversitySt. PetersburgRussia
  2. 2.St. Petersburg State Institute of TechnologySt. PetersburgRussia
  3. 3.Institute of CytologyRussian Academy of SciencesSt. PetersburgRussia

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