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Russian Journal of General Chemistry

, Volume 88, Issue 11, pp 2339–2346 | Cite as

Novel Cyanoarylporphyrazines with Triazole Groups at the Macrocycle Periphery as Potential Sensibilizers of Photodynamic Therapy and Optical Probes of Intracellular Viscosity

  • S. A. Lermontova
  • I. S. Grigoryev
  • N. N. Peskova
  • I. V. Balalaeva
  • V. P. Boyarskii
  • L. G. KlapshinaEmail author
Article
  • 6 Downloads

Abstract

Novel fluorescent dyes of the cyanoarylporphyrazine series containing peripheral triazole groups have been synthesized. Their photophysical properties and the local viscosity effect on the fluorescence have been studied. The experiments with cell cultures have revealed rapid accumulation of the dyes in the cells cytoplasm. Photo- and dark cytotoxicity of the compounds have been evaluated by means of the MTT test.

Keywords

porphyrazines template synthesis ytterbium complexes photosensibilizers optical probes of intracellular viscosity 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • S. A. Lermontova
    • 1
    • 2
  • I. S. Grigoryev
    • 1
  • N. N. Peskova
    • 2
  • I. V. Balalaeva
    • 2
  • V. P. Boyarskii
    • 3
  • L. G. Klapshina
    • 1
    • 2
    Email author
  1. 1.Razuvaev Institute of Organometal ChemistryRussian Academy of SciencesNizhny NovgorodRussia
  2. 2.Lobachevskii Nizhny Novgorod State UniversityNizhny NovgorodRussia
  3. 3.St. Petersburg State UniversitySt. PetersburgRussia

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