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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2768–2776 | Cite as

Organotin(IV) O-butyl carbonodithioates: Synthesis, characterization, in vitro bioactivities, and interaction with SS-DNA

  • F. Javed
  • S. AliEmail author
  • S. Shahzadi
  • M. N. Tahir
  • S. Tabassum
  • N. Khalid
Article
  • 35 Downloads

Abstract

Organotin(IV) O-butyl carbonodithioates [Me2SnL2], [Bu2SnL2], [Ph2SnL2], [Bu3SnL], and [Ph3SnL], where L = C4H9OCS 2 , have been successfully synthesized and characterized by FT-IR, 1H and 13C NMR, and single crystal X-ray analysis. The ligand coordinates to the tin atom via the carbonodithioate group. According to the X-ray diffraction data, the tin atom in [Me2SnL2] has distorted tetrahedral geometry. The synthesized compounds were screened in vitro for antibacterial, antifungal, antileishmanial, cytotoxic, and protein kinase inhibitory activities. The complexes [Bu3SnL] and [Ph3SnL] exhibited the highest anti-leishmanial activity that exceeded the activity of the reference drug amphotericin B, probably by blocking the function of parasitic mitochondria due to which it restricts further growth of the organisms. The ligand and the complexes have been shown to bind to DNA via intercalative interactions resulting in hypochromic effect with a minor red shift as confirmed by UV-Vis spectroscopic studies.

Keywords

organotin(IV) complexes IR NMR single crystal X-ray analysis DNA interaction antibacterial antifungal antileishmanial cytotoxicity protein kinase inhibition 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • F. Javed
    • 1
  • S. Ali
    • 1
    Email author
  • S. Shahzadi
    • 1
  • M. N. Tahir
    • 2
  • S. Tabassum
    • 3
  • N. Khalid
    • 4
  1. 1.Department of ChemistryQuaid-i-Azam UniversityIslamabadPakistan
  2. 2.Department of PhysicsUniversity of SargodhaSargodhaPakistan
  3. 3.Department of BiotechnologyQuaid-i-Azam UniversityIslamabadPakistan
  4. 4.Chemistry DivisionPakistan Institute of Nuclear Science and TechnologyNilore, IslamabadPakistan

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