Russian Journal of Coordination Chemistry

, Volume 44, Issue 11, pp 667–672 | Cite as

N,N-Bis(2-Hydroxyethyl)taurine: Synthesis, Structure, and Stability of the Complexes with Cobalt(II) and Nickel(II)

  • E. O. Zemlyakova
  • A. V. Pestov
  • P. A. Slepukhin
  • E. I. KapitanovaEmail author
  • Yu. S. Petrova
  • L. K. Neudachina


The complex formation of N,N-bis(2-hydroxyethyl)taurine with cobalt(II) and nickel(II) ions is studied. The acidic ionization constant of the ligand is determined by the potentiometric method. The stability constants of the complexes with the metal ions are calculated. Bis(N,N-di(2-hydroxyethyl)taurinato)cobalt(II) (II) and bis(N,N-di(2-hydroxyethyl)taurinato)nickel(II) monohydrate DMF disolvate (I) are synthesized, and their structures are studied by X-ray diffraction analysis (CIF file CCDC no. 1822829 (II)).


complex formation cobalt(II) nickel(II) taurine derivatives 



This study was carried out in terms of the theme of the state support using the equipment of the Center for Collective Use “Spectroscopy and Analysis of Organic Compounds” and supported by the Government of the Russian Federation (Act no. 211, contract no. 02.A03.21.0006).


  1. 1.
    Alyabyev, S.B. and Beletskaya, I.P., Russ. Chem. Rev., 2017, vol. 86, p. 689.CrossRefGoogle Scholar
  2. 2.
    Aulsebrook, M.L., Graham, B., Grace, M.R., and Tuck, K.L., Coord. Chem. Rev., 2018. doi 10.1016/ j.ccr.2017.11.018Google Scholar
  3. 3.
    Pestov, A.V., Slepukhin, P.A., and Charushin, V.N., Russ. Chem. Rev., 2015, vol. 84, p. 310.CrossRefGoogle Scholar
  4. 4.
    Haque, A., Ilmi, R., Al-Busaidi, I.J., and Khan, M.S., Coord. Chem. Rev., 2017, vol. 350, p. 320.CrossRefGoogle Scholar
  5. 5.
    Lambert, I.H., Kristensen, D.M., Holm, J.B., and Mortensen, O.H., Acta Physiologica, 2015, vol. 213, p. 191.CrossRefPubMedGoogle Scholar
  6. 6.
    Gupta, R.C., Win, T., and Bittner, S., Curr. Med. Chem., 2005, vol. 12, p. 2021.CrossRefPubMedGoogle Scholar
  7. 7.
    Good, N.E. and Izawa, S., Methods Enzymol., 1972, vol. 24, p. 53.CrossRefPubMedGoogle Scholar
  8. 8.
    Yu, Q.Y., Kandegedara, A., Xu, Y.P., and Rorabacher, D.B., Anal. Biochem., 1997, vol. 253, p. 50.CrossRefPubMedGoogle Scholar
  9. 9.
    Tian, X., Zhang, Z., Wang, S., et al., Med. Hypot., 2009, vol. 73, p. 1048.CrossRefGoogle Scholar
  10. 10.
    Yu, C., Mei, X.-T., Zheng, Y.-P., and Xu, D.-H., Eur. J. Pharm., 2014, vol. 740, p. 329.CrossRefGoogle Scholar
  11. 11.
    Bigelow, J.O., England, J., Klein, J.E.M.N., et al., Inorg. Chem., 2017, vol. 56, p. 3287.CrossRefPubMedGoogle Scholar
  12. 12.
    Petrova, Yu.S. and Neudachina, L.K., Russ. J. Inorg. Chem., 2013, vol. 58, p. 617.CrossRefGoogle Scholar
  13. 13.
    Sokolłowska, M. and Bal, W., J. Inorg. Biochem., 2005, vol. 99, p. 1653.CrossRefPubMedGoogle Scholar
  14. 14.
    Zawisza, I., Rózga, M., Poznański, J., and Bal, W., J. Inorg. Biochem., 2013, vol. 129, p. 58.CrossRefPubMedGoogle Scholar
  15. 15.
    Taha, M., Saqr, R.A., and Ahmed, A.T., J. Chem. Thermodyn., 2007, vol. 39, p. 304.CrossRefGoogle Scholar
  16. 16.
    CrysAlisPro. Agilent Technologies. Version (release 02-08-2013 CrysAlis171.NET).Google Scholar
  17. 17.
    Sheldrick, G.M., Acta Crystallogr., Sect. A: Found. Crystallogr., 2008, vol. 64, p. 112.CrossRefGoogle Scholar
  18. 18.
    Albert, A. and Serjeant E.P., Ionization Constants of Acids and Bases, London: Methuen, 1962.Google Scholar
  19. 19.
    Kostromina, N.A., Kumok, V.N., and Skorik, N.A., Khimiya koordinatsionnykh soedinenii (Chemistry of Coordination Compounds), Moscow: Vysshaya Shkola, 1990.Google Scholar
  20. 20.
    Good, N.E., Winget, G.D., Winter, W., et al., Biochemistry, 1966, vol. 5, p. 467.CrossRefPubMedGoogle Scholar
  21. 21.
    Fukada, H. and Takahashi, K., PROTEINS: Struct., Funct., and Genet., 1998, vol. 33, p. 159.CrossRefGoogle Scholar
  22. 22.
    Wyrzykowski, D., Pilarski, B., Jacewicz, D., and Chmurzynski, L., J. Therm. Anal. Calorim., 2013, vol. 111, p. 1829.CrossRefGoogle Scholar
  23. 23.
    Jiang, Y.-M., Cai, J.-H., Liua, Z.-M., and Liu, X.-H., Acta Crystallogr., Sect E: Struct. Rep. Online, 2005, vol. 61, p. 878.CrossRefGoogle Scholar
  24. 24.
    Wieghardt, K., Bossek, U., and Guttmann, M., Z. Naturforsch., A: Phys. Sci., vol. 38, p. 81.Google Scholar
  25. 25.
    Henderson, R.K., Bouwman, E., Spek, A.L., and Reedijk, J., Inorg. Chem., 1997, vol. 36, p. 4616.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • E. O. Zemlyakova
    • 1
  • A. V. Pestov
    • 1
    • 2
  • P. A. Slepukhin
    • 1
  • E. I. Kapitanova
    • 2
    Email author
  • Yu. S. Petrova
    • 2
  • L. K. Neudachina
    • 2
  1. 1.Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of SciencesYekaterinburgRussia
  2. 2.Ural Federal University Named after the First President of Russia B.N. YeltsinYekaterinburgRussia

Personalised recommendations