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Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules

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Abstract

In this study, a new series of succinimide hybrid molecules containing isothiocyanate, coumarin, isatin, and furan moieties was synthesized and screened for α-glucosidase and antioxidant activities. Preliminary results revealed that all molecules showed good α-glucosidase inhibition effectiveness. Antioxidant activities of the hybrid molecules were determined using cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) assays. Also, the radical scavenging activities of the synthesized compounds were assayed by using \({\text{ABT}}{{{\text{S}}}^{{\centerdot {\text{ + }}}}}\) and \({\text{DPP}}{{{\text{H}}}^{\centerdot }}\) methods. The results showed that all compounds exhibited moderated to high scavenging activity.

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REFERENCES

  1. 1

    Rahim, F., Ullah, H., Javid, M.T., Wadood, A., Taha, M., Ashraf, M., Shukat, A., Junaid, M., Hussain, S., Rehman, W., Mehmood, R., Sajid, M., Khan, M.N., and Khan, K.M., Bioorg. Chem., 2015, vol. 65, pp. 15–21.

  2. 2

    Wang, G., He, D., Li, X., Li, J., and Peng, Z., Bioorg. Chem., 2016, vol. 65, pp. 167–74.

  3. 3

    Özil, M., Parlak, C., and Baltaş, N., Bioorg. Chem., 2018, vol. 76, pp. 468–77.

  4. 4

    Escandón-Rivera, S., González-Andrade, M., Bye, R., Linares, E., Navarrete, A., and Mata, R., J. Nat. Prod., 2012, vol. 75, pp. 968–974.

  5. 5

    Chaudhury, A., Duvoor, C., Reddy Dendi, V.S., Kraleti, S., Chada, A., Ravilla, R., Marco, A., Shekhawat, N. S., Montales, M. T., Kuriakose, K., Sasapu, A., Beebe, A., Patil, N., Musham, C. K., Lohani, G.P., and Mirza, W., Front. Endocrinol. (Lausanne), 2017, vol. 8, pp, 1–12.

  6. 6

    Menteşe, E., Karaali, N., Akyüz, G., Yılmaz, F., Ülker, S., and Kahveci, B., Chem. Heterocycl. Compd., 2017, vol. 52, pp. 1017–1024.

  7. 7

    Yilmaz, F., Menteşe, E., and Baltaş, N., Lett. Drug. Des. Discov., 2017, vol. 14, pp. 201–208.

  8. 8

    Özyürek, M., Bektaşoǧlu, B., Güçlü, K., and Apak, R., Anal. Chim. Acta., 2009, vol. 636, pp. 42–50.

  9. 9

    Bellina, F. and Rossi, R., Tetrahedron, 2006, vol. 62, pp. 7213–7256.

  10. 10

    Obniska, J., Kaminski, K., and Chlebek, I., Acta Pol. Pharm.-Drug Res., 2009, vol. 66, pp. 663–669.

  11. 11

    Musa, M., Cooperwood, J., and Khan, M.O., Curr. Med. Chem., 2008, vol. 15, pp. 2664–2679.

  12. 12

    Borges Bubols, G., da Rocha Vianna, D., Medina-Remon, A., von Poser, G., Maria Lamuela-Raventos, R., Lucia Eifler-Lima, V., and Garcia, S.C., Mini-Reviews Med. Chem., 2013, vol. 13, pp. 318–334.

  13. 13

    Montagner, C., De Souza, S.M., Groposo, C., Delle Monache, F., Smânia, E.F.A., and Smânia, A., Zeitschrift fur Naturforsch—Sect. C,J. Biosci., 2008, vol. 63, pp. 21–28.

  14. 14

    Bansal, Y., Sethi, P., and Bansal, G., Med. Chem. Res., 2013, vol. 22, pp. 3049–3060.

  15. 15

    Kaur, M., Kohli, S., Sandhu, S., Bansal, Y., and Bansal, G., Anticancer Agents Med. Chem., 2015, vol. 15, pp. 1032–1048.

  16. 16

    Bekircan, O., Ülker, S., and Menteşe, E., J. Enzyme Inhib. Med. Chem., 2015, vol. 30, pp. 1002–1009.

  17. 17

    Salat, K., Moniczewski, A., and Librowski, T., Mini Rev. Med. Chem., 2013, vol. 13, pp. 335–352.

  18. 18

    Fhid, O.R., Zeglam, T.H., Saad, S.E., Shlaka, M., and Dao, M., World J. Pharm. Pharm. Sci., 2015, vol. 4, pp. 24–34.

  19. 19

    Kahveci, B., Yilmaz, F., Menteşe, E., and Ülker, S., Chem. Heterocycl. Compd., 2015, vol. 51, pp. 447–456.

  20. 20

    Kahveci, B., Yılmaz, F., Menteşe, E., and Ülker, S., Arch. Pharm. (Weinheim), 2017, vol. 350, pp. 1–9.

  21. 21

    Bardajee, G.R., Jafarpour, F., and Afsari, H.S., Cent. Eur. J. Chem., 2010, vol. 8, pp. 370–374.

  22. 22

    Creaven, B.S., Egan, D.A., Kavanagh, K., McCann, M., Noble, A., Thati, B., and Waslsh, M., Inorganica Chim. Acta, 2006, vol. 359, pp. 3976–3984.

  23. 23

    Danko, M., Szabo, E., and Hrdlovic, P., Dye Pigment, 2011, vol. 90, pp. 129–138.

  24. 24

    Shults, E.E., Bondarenko, S.P., Shakirov, M.M., Bagryanskaya, I.Y., and Tolstikov, G.A., Russ. J. Org. Chem., 2010, vol. 46, pp. 1709–1718.

  25. 25

    Bigi, F., Chesini, L., Maggi, R., and Sartori, G., J. Org. Chem., 1999, vol. 64, pp. 1033–1035.

  26. 26

    Kostova, I., Curr. Hiv. Res., 2006, vol. 4, pp. 347–363.

  27. 27

    Menteşe, E., Yilmaz, F., Baltaş, N., Bekircan, O., and Kahveci, B., J. Enzyme Inhib. Med. Chem., 2015, vol. 30, pp. 435–441.

  28. 28

    Özil, M., Emirik, M., Beldüz, A., and Ülker, S., Bioorganic Med. Chem., 2016, vol. 24, pp. 5103–5114.

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Correspondence to Emre Menteşe.

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The work has no studies involving humans or animals as subjects of the study.

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Authors declare that they have no conflicts of interests.

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Corresponding author: e-mail: emre.mentese@erdogan.edu.tr.

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Fatih Yılmaz, Menteşe, E. & Baltaş, N. Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules. Russ J Bioorg Chem 45, 575–584 (2019). https://doi.org/10.1134/S1068162019060402

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Keywords:

  • pyrrolidine-2,5-diones
  • α-glucosidase
  • coumarin
  • isatin
  • furan
  • antioxidant activity