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Radiochemistry

, Volume 61, Issue 1, pp 93–98 | Cite as

Preparation and Biodistribution of 99mTc-Trazodone as a Brain Imaging Probe

  • H. A. El-SabaghEmail author
  • H. M. Talaat
  • M. S. A. Abdel-Mottaleb
Article
  • 4 Downloads

Abstract

Trazodone was labeled with 99mTc by indirect method. More than 97% radiochemical yield was reached under the following optimized conditions: 100 µg of Trazodone, pH 7, 10 mg of glucoheptonate, 35 µg of stannous chloride, 185 MBq of 99mTc eluate, 20 min, room temperature. The in vitro stability and also the retention of the complex in the brain tissue allow the use of this complex as a potential brain imaging agent.

Keywords

technetium-99m brain imaging trazodone 

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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • H. A. El-Sabagh
    • 1
    Email author
  • H. M. Talaat
    • 1
  • M. S. A. Abdel-Mottaleb
    • 2
  1. 1.Hot Laboratories CentreAtomic Energy AuthorityCairoEgypt
  2. 2.Department of Chemistry, Faculty of ScienceAin-Shams UniversityCairoEgypt

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