Doklady Mathematics

, Volume 98, Issue 2, pp 439–443 | Cite as

Numerical Characteristics of the Genetic Code for the Possibility of Overlapping Genes

  • N. N. Kozlov
  • E. I. Kugushev
  • T. M. Eneev


Random changes in the standard genetic code in which its structure is preserved are considered. The hypothesis that the best possibility of overlapping genes is provided by the standard genetic code of given structure is justified. This code is determined by the condition that the total number of admissible substitutions opening closed reading frames is maximal, while the number of closed reading frames for which there is no such substitution is minimal. In terms of this criterion, the estimated probability of a random choice of the standard genetic code is less than 10–6.


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Keldysh Institute of Applied MathematicsRussian Academy of SciencesMoscowRussia
  2. 2.Faculty of Mechanics and MathematicsMoscow State UniversityMoscowRussia

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