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The Use of Microdisk Lasers Based on InAs/InGaAs Quantum Dots in Biodetection

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Abstract

It is demonstrated that microdisk lasers about 10 μm in diameter with an active region based on InAs/InGaAs quantum dots synthesized on GaAs substrates can be used for biodetection. Chimeric monoclonal antibodies against the CD20 protein that are covalently attached to the surface of microdisk lasers operating in an aqueous medium under optical pumping and room temperature were used as detectable objects. It is shown that the addition of secondary antibodies leads to an increase in the threshold power of laser generation, as well as to an increase in the full width at half maximum (FWHM) of the resonance laser line.

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REFERENCES

  1. 1

    M. L. Gorodetskii, Optical Microcavities with Giant Q‑Factor (Fizmatlit, Moscow, 2011) [in Russian].

  2. 2

    L. He, S. Özdemir, and L. Yang, Laser Photon. Rev. 7, 60 (2013). https://doi.org/10.1002/lpor.201100032

  3. 3

    X. F. Jiang, C. L. Zou, L. Wang, Q. Gong, and Y. F. Xiao, Laser Photon. Rev. 10, 40 (2016). https://doi.org/10.1002/lpor.201500163

  4. 4

    K. Y. Yang, Y. O. Dong, S. H. Lee, Q. F. Yang, X. Yi, B. Shen, H. Wang, and K. Vahala, Nat. Photon. 12, 297 (2018). https://doi.org/10.1038/s41566-018-0132-5

  5. 5

    J. S. Levy, A. Gondarenko, M. A. Foster, A. C. Turner-Foster, A. L. Gaeta, and M. Lipson, Nat. Photon. 4, 37 (2010). https://doi.org/10.1038/nphoton.2009.259

  6. 6

    M. R. Foreman, J. D. Swaim, and F. Vollmer, Adv. Opt. Photon. 7, 168 (2015). https://doi.org/10.1364/AOP.7.000168

  7. 7

    X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, Anal. Chim. Acta 620, 8 (2008). https://doi.org/10.1016/j.aca.2008.05.022

  8. 8

    J. Yang and L. J. Guo, IEEE J. Sel. Top. Quant. Electron. 12, 143 (2006). https://doi.org/10.1109/JSTQE.2005.862953

  9. 9

    Q. Lu, X. Chen, L. Fu, S. Xie, and X. Wu, Nanomaterials 9, 479 (2019). https://doi.org/10.3390/nano9030479

  10. 10

    T. J. Kippenberg and K. J. Vahala, Opt. Express 15, 17172 (2007). https://doi.org/10.1364/OE.15.017172

  11. 11

    C. Dong, V. Fiore, M. C. Kuzyk, and H. Wang, Science (Washington, DC, U. S.) 338, 1609 (2012). https://doi.org/10.1126/science.1228370

  12. 12

    D. Armani, T. Kippenberg, S. Spillane, and K. Vahala, Nature (London, U.K.) 421, 925 (2003). https://doi.org/10.1038/nature01371

  13. 13

    X. Jiang, L. Shao, S. X. Zhang, X. Yi, J. Wiersig, L. Wang, Q. Gong, M. Loncar, L. Yang, and Y. F. Xiao, Science 358, 344 (2017). https://doi.org/10.1126/science.aao0763

  14. 14

    Q. Lu, S. Liu, X. Wu, L. Liu, and L. Xu, Opt. Lett. 41, 1736 (2016). https://doi.org/10.1364/OL.41.001736

  15. 15

    J. Ward and O. Benson, Laser Photon. Rev. 5, 553 (2011). https://doi.org/10.1002/lpor.201000025

  16. 16

    N. V. Kryzhanovskaya, E. I. Moiseev, Y. S. Polubavkina, M. V. Maximov, D. V. Mokhov, I. A. Morozov, M. M. Kulagina, Y. M. Zadiranov, A. A. Lipovskii, M. Tang, M. Liao, J. Wu, S. Chen, H. Liu, and A. E. Zhukov, Laser Phys. Lett. 15, 015802 (2018). https://doi.org/10.1088/1612-202X/aa9306

  17. 17

    M. Fetisova, N. Kryzhanovskaya, I. Reduto, E. Moiseev, S. Blokhin, K. Kotlyar, S. Scherbak, A. Lipovskii, A. Kornev, A. Bukatin, M. Maximov, nd A. Zhukov, J. Phys.: Conf. Ser. 1124, 051007 (2018). https://doi.org/10.1088/1742-6596/1124/5/051007

  18. 18

    Q. Yu, J. Hui, P. Wang, and X. Wang, Inorg. Chem. 51, 9539 (2012). https://doi.org/10.1021/ic301371q

  19. 19

    W. Qu, B. Meng, Y. Yu, and S. Wang, Mater. Sci. Eng. C 76, 646 (2017). https://doi.org/10.1016/j.msec.2017.03.036

  20. 20

    L. Diéguez, N. Darwish, M. Mir, E. Martínez, M. Moreno, and J. Samitier, Sens. Lett. 7, 851 (2009). https://doi.org/10.1166/sl.2009.1161

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Correspondence to M. V. Fetisova.

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The authors declare that they have no conflict of interest.

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Translated by O. Kadkin

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Fetisova, M.V., Kornev, A.A., Bukatin, A.S. et al. The Use of Microdisk Lasers Based on InAs/InGaAs Quantum Dots in Biodetection. Tech. Phys. Lett. 45, 1178–1181 (2019). https://doi.org/10.1134/S106378501912006X

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Keywords:

  • biosensor
  • semiconductor laser
  • microdisk laser
  • quantum dots
  • photoluminescence.