Structure and Physicochemical Mechanisms of Interaction of Bone Tissue with Titanium Implants in Cases of Tuberculous Osteitis

  • 6 Accesses


The structural and physicochemical mechanisms of interaction of bone tissue with titanium implants under conditions of tuberculous osteitis are studied using scanning electron microscopy, X-ray diffraction analysis, IR spectroscopy, and thermal analysis. Physiological regeneration of bone tissue during treatment of tuberculous osteitis is accompanied by an increase in the organic component, embrittlement of the mineral phase of the bone matrix, and its decomposition to fine particles. The presence of titanium implants under physiological conditions contributes to the activation of the synthesis of the apatite phase in the regenerating bone. The primary mechanism of implantation osteogenesis in tuberculous osteitis is the formation of an inorganic phase of hydroxyapatite mainly in the regions of destruction of the titanium alloy.

This is a preview of subscription content, log in to check access.

Access options

Buy single article

Instant unlimited access to the full article PDF.

US$ 39.95

Price includes VAT for USA

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.


  1. 1

    A. A. Gaidash, L. N. Sinitsa, O. A. Babenko, and A. A. Lugovskoy, J. Osteoporosis 2011, 162041 (2011).

  2. 2

    S. M. Jung, K. W. Kim, C.-W. Yang, S.-H. Park, and J. H. Ju, J. Immunol. Res. 2014, 263625 (2014).

  3. 3

    O. I. Agapova, Sovrem. Tekhnol. Med. 9, 190 (2017).

  4. 4

    V. K. Krut’ko, A. I. Kulak, and O. N. Musskaya, Inorg. Mater. 53, 429 (2017).

  5. 5

    O. N. Musskaya, A. I. Kulak, V. K. Krut’ko, Yu. A. Lesnikovich, V. V. Kazbanov, and N. S. Zhitkova, Inorg. Mater. 54, 117 (2018).

  6. 6

    T. D. Sargeant, M. O. Guler, S. M. Oppenheimer, A. Mata, R. L. Satcher, D. C. Dunand, and S. I. Stupp, Biomaterials 29, 161 (2008).

  7. 7

    A. A. Yanovska, A. S. Stanislavov, L. B. Sukhodub, V. N. Kuznetsov, V. Yu. Illiashenko, S. N. Danilchenko, and L. F. Sukhodub, Mater. Sci. Eng. C 36, 215 (2014).

  8. 8

    F. Barrerea, M. M. E. Snelc, C. A. Van Blitterswijka, K. De Groota, and P. Layrollea, Biomaterials 25, 2901 (2004).

  9. 9

    S. Ichinose, T. Muneta, I. Sekiya, S. Itoh, H. Aoki, and M. Tagami, J. Mater. Sci.: Mater. Med. 14, 79 (2003).

  10. 10

    A. L. Boskey, E. Donnelly, E. Boskey, L. Spevak, Y. Ma, W. Zhang, J. Lappe, and R. R. Recker, J. Bone Miner. Res. 31, 1070 (2016).

  11. 11

    S. A. Lemesheva, O. A. Golovanova, and S. V. Turenkov, Chem. Sustainable Dev. 17, 327 (2009).

  12. 12

    S. A. Lemesheva, O. A. Golovanova, I. V. Muromtsev, and S. V. Turenkov, Vestn. Omsk. Univ., No. 2, 106 (2010).

Download references

Author information

Correspondence to O. N. Musskaya.

Ethics declarations


The authors declare that they do not have any conflicts of interest.


The experimental protocols, including the content and method of euthanasia, agree with the ethics committee of the St. Petersburg Research Institute of Phthisiopulmonology and comply with the Rules for the Maintenance of Laboratory Animals, approved by Order of the Ministry of Health of the Russian Federation.

Additional information

Translated by O. Zhukova

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Musskaya, O.N., Krut’ko, V.K., Gaidash, A.A. et al. Structure and Physicochemical Mechanisms of Interaction of Bone Tissue with Titanium Implants in Cases of Tuberculous Osteitis. Tech. Phys. 64, 1898–1903 (2019) doi:10.1134/S1063784219120193

Download citation