Comparison of the Structural Features of Micron and Submicron Vaterite Particles and Their Efficiency for Intranasal Delivery of Anesthetic to the Brain
Nanostructured spherical calcium carbonate particles with average sizes of 3.8 µm and 550 nm have been fabricated. Optimal conditions for adsorption of central anesthetic loperamide on these particles are found. The influence of particle size on the adsorption efficiency is studied. The efficiency of micron and submicron vaterite particles as carriers for intranasal loperamide delivery is compared using in vivo tests on laboratory animals.
This study was performed using equipment of the Shared Research Center of the Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences with the support of the Ministry of Science and Higher Education within the State assignment FSRC “Crystallography and Photonics” RAS (no. 007-ГЗ/Ч3363/26) in the part of designing containers and studying their properties. Synchrotron studies were carried out on a unique research object, specialized Kurchatov Synchrotron Radiation Source “KSRS-Kurchatov,” with support of the Ministry of Education and Science of the Russian Federation (project code RFMEFI61917X0007).
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