Biology Bulletin

, Volume 45, Issue 4, pp 325–336 | Cite as

Mendelian Transmission Ratio Distortion (TRD) and Factors Determining the Low Frequency of the t-Haplotypes in Wild Populations of the House Mouse Mus musculus of Russia and the Neighboring Countries of Eurasia

  • V. G. PetrosyanEmail author
  • L. D. Safronova
  • A. I. Chekunova
  • N. N. Dergunova


The results of analysis of the frequencies of t-alleles and heterozygous +/t individuals of house mice of different subspecies (musculus, bactrianus, tataricus, wagneri, and gansuensis) are presented for the natural populations inhabiting eight cities and five regions of Russia and adjacent countries of Eastern Europe and Asia. It is shown that the frequencies of t-alleles are 0.18 ± 0.03 in small samples (1–30 individuals) and 0.09 ± 0.06 in medium-sized samples (31–60 individuals). The factors that reduce the frequencies of t-alleles in natural populations and the mechanisms that prevent invasion and fixation of t-mutant alleles in the Mus musculus genome are discussed.


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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • V. G. Petrosyan
    • 1
    Email author
  • L. D. Safronova
    • 1
  • A. I. Chekunova
    • 2
  • N. N. Dergunova
    • 1
  1. 1.Severtsov Institute of Ecology and EvolutionRussian Academy of SciencesMoscowRussia
  2. 2.Koltzov Institute of Developmental BiologyRussian Academy of SciencesMoscowRussia

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