Journal of Analytical Chemistry

, Volume 74, Issue 11, pp 1089–1095 | Cite as

Simultaneous Determination of Anthraquinone and Bisphenol A in Pulp and Paper Products by High Performance Liquid Chromatography‒Tandem Mass Spectrometry

  • A. S. Amosov
  • N. V. Ul’yanovskii
  • D. S. KosyakovEmail author


A procedure for the rapid simultaneous determination of anthraquinone and bisphenol A in paper and cardboard is proposed based on a combination of extraction with subcritical methanol and subsequent analysis of the extracts by HPLC‒tandem mass spectrometry. The achieved limits of detection are 25 and 250 µg/kg for anthraquinone and bisphenol A, respectively, and fully meet present-day safety requirements for pulp and paper products. The total duration of the analysis, including sample preparation, is not more than 45 min. The sensitivity of anthraquinone determination is 1‒2 orders of magnitude higher than that of the known procedures, including those with the preconcentration of analytes. The results obtained were successfully used to study paper and cardboard samples, in most of which unacceptably high levels of the anthraquinone concentration were found.


HPLC tandem mass spectrometry anthraquinone bisphenol A pressurized liquid extraction paper cardboard 



The work was done using the equipment of the Core Facility Center “Arktika” of the Lomonosov Northern (Arctic) Federal University with the financial support from the Ministry of Education and Science of the Russian Federation, project no. 4.2518.2017/4.6.


  1. 1.
    Sixta, H., Handbook of Pulp, Weinheim: Wiley, 2006.CrossRefGoogle Scholar
  2. 2.
    Abildgaard, A., Mikkelsen, S.H., and Stuer-Lauridsen, F., Survey of chemical substances in paper handkerchiefs and toilet paper, in Survey of Chemical Substances in Consumer Products, 2003, no. 34, p. 65.Google Scholar
  3. 3.
    Hart, P.W. and Rudie, A.W., Tappi J., 2014, vol. 13, no. 10, p. 23.CrossRefGoogle Scholar
  4. 4.
    Some chemicals present in industrial and consumer products, food and drinking-water: Anthraquinone, IARC Monogr. Eval. Carcinog. Risks Hum., vol. 101, Lyon, France: World Health Organization, International Agency for Research on Cancer, 2012, p. 41.Google Scholar
  5. 5.
    BfR removes anthraquinone from its list of recommendations for food packaging, BfR opinion no. 005/2013, February 12, 2013.Google Scholar
  6. 6.
    Biedermann, S., Tschudin, P., and Grob, K., Anal. Bioanal. Chem., 2010, vol. 398, no. 1, p. 571.CrossRefGoogle Scholar
  7. 7.
    Update on Bisphenol A for Use in Food Contact Applications, U.S. Food and Drug Administration, January, 2010.Google Scholar
  8. 8.
    European commission, Commission Regulation (EU) no. 10/2011 of 14 January 2011 on Plastic Materials and Articles Intended to Come into Contact with Food, Off. J. Eur. Union, 2011, no. 1, p. 12.Google Scholar
  9. 9.
    Brønstad, J.O., Schroder, K.H., and Friestad, H.O., Anal. Chim. Acta, 1980, vol. 119, p. 243.CrossRefGoogle Scholar
  10. 10.
    Deng, K.Q., Liu, X.Y., Li, C.X., Hou, Z.H., and Huang, H.W., Anal. Methods, 2017, vol. 9, no. 37, p. 5509.CrossRefGoogle Scholar
  11. 11.
    Tan, J., Shi, Z.H., Hu, Y.F., Xiao, X.H., and Li, G.K., Chin. J. Anal. Chem., 2017, vol. 45, no. 12, p. 2011.Google Scholar
  12. 12.
    Chai, X.S., Yang, X.T., Hou, Q.X., Zhu, J.Y., and Danielsson, L.-G., in Proc. Int. Symp. Wood and Pulping Chemistry, 2003, p. 203.Google Scholar
  13. 13.
    Batista, A.D. and Rocha, F.R.P., Int. J. Environ. Anal. Chem., 2013, vol. 93, no. 13, p. 1402.CrossRefGoogle Scholar
  14. 14.
    Cai, Y.O., Jiang, G.B., Liu, J.F., Liang, X., Yao, Z.W., Liu, J.M., Liu, Y.J., and Zhou, Q.X., Anal. Lett., 2004, vol. 37, no. 4, p. 739.CrossRefGoogle Scholar
  15. 15.
    Sanchisa, Y., Yusàa, V., and Coscollà, C., J. Chromatogr. A, 2017, vol. 1490, p. 22.CrossRefGoogle Scholar
  16. 16.
    NCASI Method AQ-S108.01: Anthraquinone in Uncoated Papers and Market Pulps by Soxhlet Extraction and GCMS, Technical Bulletin no. 953. Research Triangle Park, NC: National Council for Air and Stream Improvement, 2008.Google Scholar
  17. 17.
    Yang, K.R., Seo, H.S., Lee, Y.S., Choi, M.H., and Hong, J., Anal. Methods, 2015, vol. 7, no. 15, p. 6060.CrossRefGoogle Scholar
  18. 18.
    Schneiderman, M.A., Sharma, A.K., and Locke, D.C., J. Chromatogr. A, 1987, vol. 409, p. 343.CrossRefGoogle Scholar
  19. 19.
    Revenga, J., Rodríguez, F., and Tijero, J., J. Chromatogr. A, 1995, vol. 712, p. 372.CrossRefGoogle Scholar
  20. 20.
    Ul’yanovskii, N.V., Kosyakov, D.S., Panfilova, M.V., Zhdanov, A.A., and Bogolitsyn, K.G., Zavod. Lab., Diagn. Mater., 2012, vol. 79, no. 6, p. 18.Google Scholar
  21. 21.
    Hao, Z.M., Xiao, Y.P., Jiang, L.L., Bai, W.D., Huang, W.S., and Yuan, L.P., Food Anal. Methods, 2018, vol. 11, no. 2, p. 589.CrossRefGoogle Scholar
  22. 22.
    Gao, L.H., Zou, J., Liu, H.H., Zeng, J.B., Wang, Y.R., and Chen, X., J. Sep. Sci., 2013, vol. 36, no. 7, p. 1298.CrossRefGoogle Scholar
  23. 23.
    Yalcin, M.C., Gecgei, C., and Battal, D., J. Turk. Chem. Soc. A, 2016, vol. 3, no. 3, p. 167.Google Scholar
  24. 24.
    Pérez-Palacios, D., Fernández-Recio, M.Á., Moreta, C., and Tena, M.T., Talanta, 2012, vol. 99, p. 167.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. S. Amosov
    • 1
  • N. V. Ul’yanovskii
    • 1
  • D. S. Kosyakov
    • 1
    Email author
  1. 1.Lomonosov Northern (Arctic) Federal University, Core Facility Center “Arktika”ArkhangelskRussia

Personalised recommendations