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Journal of Analytical Chemistry

, Volume 74, Issue 6, pp 528–533 | Cite as

Oxidative Coupling Reaction for the Determination of Lurasidone

  • M. S. SudhirEmail author
  • R. Venkata NadhEmail author
  • H. Manjunatha
ARTICLES
  • 13 Downloads

Abstract

A simple, sensitive, precise, accurate, highly reproducible and economical, visible spectrophotometric method for the determination lurasidone in bulk form was developed and validated. The method is based on the formation of an oxidative coupling product by the reaction of lurasidone with 3-methylbenzothiazolin-2-one hydrazone as a chromogenic reagent in presence of ferric chloride. The linear regression analysis data for the calibration plot showed good linear relationship within the concentration range of 0–100 μg/mL with a correlation coefficient (r) value of 0.9997. The limits of detection and quantitation are 0.6 and 1.7 µg/mL, respectively. The method was tested and validated according to ICH guidelines. The results demonstrated that the procedure is accurate, precise and reproducible (RSD < 2%).

Keywords:

lurasidone validation oxidative coupling 3-methylbenzothiazolin-2-one hydrazone (MBTH) 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Department of Chemistry, Sri Subbaraya and Narayana CollegeNarasaraopetIndia
  2. 2.GITAM University – Bengaluru CampusKarnatakaIndia

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